| Patients who suffer from severe chronic periodontitis have a serious destruction in alveolar bone. If one tooth is clinically diagnosed that there is no retention value, it must be extracted in time. After extraction, alveolar bone appears further absorption. A serious lack of alveolar bone and inflammation of tooth socket increase the difficulty of the late implanting and repair, affecting aesthetic effect. If the tooth was extracted and immediately did site preservation, it could save as much as possible the amount of alveolar bone, providing good bone conditions for implanting, helping repair the late implanting. Site preservation is that various types of biomaterials are implanted in extraction sockets in order to reduce the absorption of alveolar bone. This experiment used biological materials including Bio-Oss bone, growth factors, and biological membrane of acellular dermal matrix. Bio-Oss bone is xenograft bone material and used widely in clinical that is extracted from calf inorganic bone, and it is porous and can play a good role in bone leading, but it lacks osteoinductive effect, and therefore growth factors were added in this experiment. Platelet-rich fibrin(PRF) can slowly release large amounts of growth factors. Moreover, it contains a large number of white blood cells which can increase the organization’s ability to prevent infection and promote wound healing. Recombinant bovine basic fibroblast growth factor(b FGF) is a polypeptide growth factor that can promote cell mitosis and repair and regeneration of cells, improving blood circulation, reducing healing time. Plaque is the main cause of periodontal disease and the most basic treatment of chronic periodontitis is to eliminate gingival and subgingival plaque to control periodontal disease, to improve success rate of post-surgery and reduce risk of infection. This experiment used two different growth factors PRF or b FGF and Bio-Oss bone, covering ADM biological membrane to implant into extraction sockets of patients who suffer from severe chronic periodontitis for sites preservation. To provide a theoretical basis and practical guidance of site preservation of patients who suffer severe chronic periodontitis.Objective To observe the clinical effect of site preservation using platelet-rich fibrin or basic fibroblast growth factor in patients who suffer from serious chronic periodontitis.Methods 32 patients were extracted the teeth, and have an exhaustive debridement in the sockets, saline rinsing, minocycline processing for 5 minutes after periodontal basic therapy, then they were divided into three groups. Group one was implanted platelet-rich fibrin which was made from blood of patients and Bio-Oss into the sockets. Group two was implanted basic fibroblast growth factor and Bio-Oss into the sockets. Group three was only implanted Bio-Oss, not used any growth factor. After six months, clinical effect of all groups was observed.Results After two weeks, 32 patients were observed that all extraction sockets healed well and had no significant inflammatory response. After 6 months, dental extraction wounds of three groups were observed that they were fully closed. The shape of gingival in PRF group was the most full. Three groups maintained bone height and bone density increased. Probing depth(PD), bleeding on probing(BOP) and gingival recession(GR) in three groups were significantly different before treatment and after 6 months(P<0.05), there was no significant difference between the groups(P>0.05). There are significant differences in alveolar vertical PRF group or b FGF group and control group to compare the amount of alveolar bone vertical bone resorption(P<0.05).Conclusions Using growth factor such as platelet-rich fibrin or basic fibroblast growth factor can improve the condition of soft and hard tissue, decrease vertical height of alveolar bone and maintain more bone mass in ridge preservation of serious chronic periodontitis. |
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