Effect Of CGF And DBBM Ratio On Site Preservation

Objective: Different ratios of CGF and DBBM were filled in rabbit teeth extraction socket,to explore the ratio of better site preservation effect.Methods: Groups A,B and C were CGF mixed with DBBM at the ratio of 2:1,1:1 and 1:2.Group D was control group.The teeth extraction socket of the first premolar on both sides of the lower jaw was filled with the same ratio.The left operation was performed on 8 weeks after the right operation.Rabbits were sacrificed 4 weeks after left operation.Amount of new bone formation and the degree of bone maturity were observed histologically at 4 and 12 weeks using HE and Masson stain.X-rays were used to evaluate the alveolar bone absorption at 4 and 12 weeks.All images were analyzed by image-pro Plus6.0.Results: At the same time point,the order of new bone formation was group A,group B,group C and group D(P < 0.05),alveolar bone resorption in group A,group B and group C was no statistical difference(P >0.05),and they all smaller than group D(P < 0.05).At the same group,the bone mass at 12 weeks was higher than that at 4 week(P < 0.05),alveolar bone resorption was higher than 4 weeks(P < 0.05).Conclusions: When the ratio of CGF and DBBM was 2:1,1:1 and 1:2,better site preservation effect was obtained,and 2:1 was the best.