Study On The Influencing Factors And The Self-efficacy Intervention Of Gastrointestinal Reaction In Patients With Lung Cancer During Chemotherapy

Objective:①To investigate the general situation of gastrointestinal reaction and explore the influencing factors of lung cancer patients during chemotherapy。②To investigate the intervention on gastrointestinal reaction in patients with lung cancer during chemotherapy.Methods:This study was divided into two stages and taked convenience sampling method. In the investigation stage.120 cases of lung cancer patients receiving chemotherapy were investigated by the general questionnaire、special features questionnaire、Medical CopingModes Questionnaire (MCMQ)、Social Support Rating Scale(SSRS) and gastrointestinal reaction assessment form. In the intervention stage,90 patients who met the criteria of admission were divided into the control group and the intervention group according to the time of admission. The control group received usual care, while the intervention group implemented self-efficacy intervention on the basis of it. Two groups of patients were measured with SSRS, MCMQ, general self-efficacy scale (GSES) before, during and after intervention, and evaluated weight, serum albumin, serum total protein and gastrointestinal reaction levels, respectively.Results: ①The incidence of nausea、constipation、vomiting、abdominal distension、 Oral problems and diarrhea in lung cancer patients during chemotherapy were 89.2%, 68.3%,53.3%,43.3%,22.5% and 16.7%, respectively.②Marital status、KPS score、 subjective support and confrontation are the main influencing factors of oral problems, which could explain 42.3% of the variation. Informed status、the total score of social support and yield are the main influencing factors of nausea, which could explain 51.5% of the variation. Occupation、the total score of social support and subjective support were the main influencing factors of vomiting, which can explain 37.4% of the variation. Education level、smoking index and the total score of social support were the main influencing factors of constipation and could explain the variation of 35.5%. KPS score and confrontation were the main influencing factors of diarrhea and could explain the variation of 24.2%. KPS score and the total score of social support were the main factors affecting abdominal distension, explained 39.2% of the variability.③ After repeated measurement data analysis of variance, two groups of observation indexes (except weight) were affected by time, some existed interaction between time and groups. The changes were different and had statistical significance (P<0.05) in utilization of support, yield, general efficacy and gastrointestinal reaction between different groups.Results: ①The incidence of gastrointestinal reaction in chemotherapy patients with lung cancer was high, which was influenced by occupation、marital status、education level、informed status、smoking index、KPS score、social support and coping styles. It is suggested that the clinical medical personnel should provide different interventions according to the different informed status、smoking index、KPS score、social support and coping styles, and so forth. ② Self-efficacy intervention can reduce gastrointestinal side effects of chemotherapy in lung cancer patients and has better feasibility and effectiveness through clinical evaluation.