| Objectives:Using meta-analysis to systematically review clinical random controlled trials that have examined the effects of inulin-type fructans on atherosclerosis associated blood lipids profile and glycometabolism, and to provide references for dietary strategy of atherosclerosis and diabetes prevention. The two specific parts are:1. Meta-analysis of effect of inulin-type fructans on atherosclerosis associated blood lipids profile (HDL-C, TG,LDL-C); 2. Meta-analysis of effect of inulin-type fructans on glycometabolism (FPQ HbA1c).Methods:The two meta-analysis were carried out according to the following steps:relevant literatures were comprehensively searched in databases (The first part concludes PubMed, Embase, CNKI,CBM, VIP and WanFang Databases, while the second concludes PubMed, Embase, Medline, Cochrane). Eligible studies were selected according to the inclusion and exclusion criteria. Then the quality evaluation (JADAD) and data extraction were conducted. Meta-analysis and publication bias were calculated using software Review Manager5.1 and Stata11.0 provided by The Cochrane Collaboration.Results:1. Meta-analysis of effect of inulin-type fructans on atherosclerosis associated blood lipids profile:Twenty two studies were included in this study. The total sample size was 822, and the numbers of treatment and control groups were 413 and 409, respectively. The results of the meta-analysis showed that the pooled WMD (95% confidence interval) of the effect of inulin-type frutans on HDL-C, TG and LDL-C were 0.05 mmol/L (0.01,0.08),-0.08 mmol/L (-0.14,-0.01) and -0.16 mmol/L (-0.25,-0.06), respectively. So the HDL-C level was increased, while the TG and LDL-C level were decreased dramatically in the overall pool analysis. The subgroup analysis results revealed that the level of TG decreased dramatically by 0.17 mmol/L (-0.33,-0.01) in the dyslipidemia group. In the diabetes group, a noticeable increment of 0.15 mmol/L (0.08,0.23) was found in HDL-C and a reduction of 0.30 mmol/L (-0.54,-0.05) was found in TG.In addition, no statistical changes of the blood lipids parameters were found.2. Meta-analysis of effect of inulin-type fructans on glycometabolism: Sixteen studies were included in this study. The total sample size was 536, and the numbers of treatment and control groups were 271 and 265, respectively. The results of the meta-analysis showed that the pooled WMD (95% confidence interval) of the effect of inulin-type frutans on FPG and HbAlc were-0.11 mmol/L (-0.21,-0.01) and -0.36%(-0.76,0.04), respectively. So the FPG level was increased dramatically, while the HbAlc level was not changed statistically in the overall pool analysis. The subgroup analysis results revealed that the level of FPG and HbAlc decreased dramatically by 0.72 mmol/L (-1.01,-0.42) and 0.59%(-0.92,-0.25) respectively in the diabetes group. In the non-diabetes group, no statistical change was found in FPG.Conclusions:1. Inulin-type fructans administration plays a positive role in the prevention of ASCVD. The serum level of HDL-C could be increased, while TG and LDL-C could be decreased through administration of 14g/d inulin-type fructans. Dyslipidemia and diabetes patients could benefit more from this dietary strategy.2. Inulin-type fructans administration plays a positive role in the prevention of DM. The level of FPG could be decreased through administration of 13g/d inulin-type fructans. Diabetes patients could benefit more from this dietary strategy, both of whose FPG and HbAlc could be decreased much more dramatically. |
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