The Clinical Efficacy Of Prucalopride In The Treatment Of Functional Constipation

Objective:To observe the clinical efficacy and safety of prucalopride in the treatment of functional constipation (FC).Methods:This experiment was taking a self controlled prospective study. The patients were taking prucalopride 2 mg,1 time per day. The total course was four weeks. Eighty-seven female patients with FC according to Rome-Ⅲ diagnostic criteria were observed about the defecate frequency, stool property, constipation symptom grade and adverse drug reaction before and after treatment.Results:Before the treatment, the defecate frequency of the patients was few (the defecate frequency for a week was 2.20±0.48 times), the patients’ stool was very dry (the score of the stool property was 1.75±0.56 points), their bowel movement was especially difficult (the constipation symptom grade was 2.32±0.63 points). During the period of treatment, the defecate frequency was gradually increased (in the second week of treatment was 4.41±0.62 times, in the fourth week of treatment was 5.82±0.75 times), the stool property was gradually improved(in the second week of treatment was 3.72±0.58 points, in the fourth week of treatment was 4.55±0.56 points), the constipation symptom grade of the patients was also improved(in the second week of treatment was 1.17±0.43 points, in the fourth week of treatment was 0.49±0.50 points). Compared each index before and after the treatment, the difference was statistically significantly (P<.01). During the period of treatment, the main adverse drug reaction was diarrhea, headache and nausea. All the adverse drug reaction was mild. There was no significant adverse drug reaction during the study.Conclusion:Prucalopride is a safe and effective treatment for patients with FC.