CA72-4 CEA CYFRA21-1 For NSCLC Study On Relationship Between Pathologic Types, Clinical Grading

Objective The incidence and mortality of lung cancer which poses a serious threat to human health continues to grow. Early diagnosis of lung cancer, combined with timely, reasonable and targeted therapy has become the key to the prognosis of patients. Detection of tumor markers in lung cancer, which is considered as a fast, easy, effective, non-invasive and better compliance way, has become the first choice in clinic. Clinical treatment has important significance for the preliminary judgment of the pathological type, clinical staging of lung cancer; prediction of review, the continuity of the dynamic monitoring and curative effect after the treatment; the reasonable choice of diagnosis. The combined detection of tumor markers for lung cancer diagnostic accuracy, sensitivity, specificity were improved. CA72-4 as initial markers in the diagnosis of gastric cancer was used in clinical practice. The study found that it also has a higher expression in lung cancer, but rarely seen as markers of lung cancer in clinical. CEA and CYFRA21-1 are earlier used as diagnostic markers of lung cancer. This topic is indexes of three patients with non small cell lung cancer serum CA72-4, CEA, CYFRA21-1 for joint detection, analysis the relationship between the type, and non small cell lung cancer staging, and for providing help on clinical diagnosis and treatment of non-small cell lung cancer, curative effect and prognosis, providing certain reference on how to select the application of markers.Methods Randomly selected from the Affiliated Hospital of Hebei University in 2013 September-2015 year in January for the first time the in-patient treatment for 95 patients with non small cell lung cancer, All patients were confirmed by pathology, including 72 cases of male, female 23 cases, 37 cases of squamous cell carcinoma, 58 cases adenocarcinoma. In accordance with the International Association for the study of lung cancer lung cancer staging in 2009, 7th edition staging criteria,9 cases of stageⅠ, 23 cases of Ⅱ stage, 10 cases in stage Ⅲ, Ⅳ in 53 cases. Control group: normal healthy crowd, 14 males and 10 females, aged 45-71 years, average age of 58 ± 7. Venous blood 3ml are taken on an empty stomach in the morning, test serum levels of CA72-4, CEA, CYFRA21-1, using SPSS19.0 medical statistical software to analyze the relationship between three kinds of tumor markers and pathological Type, clinical staging of non-small cell lung cancer. Result The results showed that serum CA72-4, CEA, CYFRA21-1 associated with histological type, the level of CEA, CA72-4 is higher in Adenocarcinoma than in squamous cell carcinoma, P<0.05; the level of CYFRA21-1 is higher in squamous cell carcinoma than in Adenocarcinoma, P<0.05. Serum levels are differences in the Clinical staging, stageⅣ > stage Ⅲ> stage Ⅱ> stageⅠ, P<0.05. Joint Detection Sensitivity and accuracy can be improved. Conclusions There is a correlation between the levels of serum CA72-4, CEA, CYFRA21-1 and histological types and clinical stages of non-small cell lung cancer, CA72-4 can also be used as markers for detection of non- small cell lung cancer. CEA, CA72-4 levels in adenocarcinoma is higher, suggesting that the two combined detection in the diagnosis of lung adenocarcinoma is better. CYFRA21-1 levels were higher in squamous cell carcinoma. The later clinical stage, the higher the level of markers.markers of single detection sensitivity is low.Combined testing could increase the sensitivity and accuracy.