Study On The Correlation Of Preoperative Peripheral Blood Inflammation Index And Tumor Markers In Clinicopathological Staging Of Gastric Cancer

Objective:To explore the application value of preoperative peripheral blood inflammation markers and tumor markers in the clinicopathological staging of gastric cancer,construct a clinical prediction model to evaluate the predictive value of individual indicators and comprehensive indicators in the clinicopathological staging of gastric cancer,lastly evaluate the predictive ability of the model.Methods:Clinical information of patients undergoing radical gastrectomy for gastric cancer in the Department of Gastrointestinal Surgery of the Second Affiliated Hospital of Nanchang University from December 2019 to May 2021 was collected.Descriptive and predictive methods were used to analyze the collected data,and patients were divided into early and advanced groups based on pathological results.The ROC curve was used to calculate the best cut-off value of each index and grouped according to this.The correlation between the collected indicators and the clinicopathological characteristics of gastric cancer patients was analyzed by univariate and multivariate Logistic regression.Finally,the regression model was used to draw a Nomogram to evaluate the predictive value of combined detection for the clinicopathological staging of gastric cancer.The double standard of C index and calibration curve is used to test the accuracy of the predictive model.Results:A total of 118 gastric cancer patients were included in this study,including 29(24.6%)cases of stage I,28(23.7%)cases of stage II,and 61(51.7%)cases of stage III;pathological types: 55(46.7%)cases with high differentiation,63(53.3%)cases with low differentiation;T1: 21(17.8%)cases,T2: 11(9.3%)cases,T3: 52(44.1%)cases,T4: 34(28.8%)cases;21(17.8%)cases of early gastric cancer and 97(82.2%)cases of advanced gastric cancer.SII was significantly correlated with tumor invasion depth,lymph node metastasis,clinicopathological stage,tumor size,and CA125.The results of univariate analysis showed that(IL8,CEA,CA199,NLR PLR,SII,Size,Grade)and the pathological stage of advanced gastric cancer were significantly correlated.Logistic regression analysis showed that(IL8,CA199,SII,Size,Grade)were independent risk factors.The areas under the curves of IL8,CA199,SII,Size,and Grade were 0.601,0.708,0.697,0.688,and 0.708,respectively.The area under the curve of the combined test was 0.922,which was much higher than the area under the curve of any single indicator,and its sensitivity,specificity,and accuracy were all high.The results showed that the combined detection method was more superior than the single detection method.Conclusion:The expression of peripheral blood inflammatory markers and tumor markers levels in gastric cancer patients is closely related to the pathological stage of gastric cancer,and the biological behavior of gastric cancer can be evaluated by these indexes.Compared with a single index,the combined index constructed with IL8,CA199,SII,Size,and Grade can significantly improve the predictive ability of the clinical stage of gastric cancer.The biggest advantage of combined detection is that it can overcome the shortcomings of a single index,which will have great application value and significance in clinical diagnosis.