Correlation Of Tumor Markers And Pathological Staging With Non Small Cell Lung Cancer

Objective To investigate the union expression of CEA、NSE and CYFRA21-1in non-small cell lung cancer and to explore the relationship between the tumor markers and pathological staging of non-small cell lung cancer.Methods143patients (malel0land female42, from31to78years old,average58.6years old) in non-small cell lung cancer with their postoperative pathological dates were collected.The expression results of CEA、NSE and CYFRA21-1were measured before operation in all patients and then were used to study the correlation between them and tumor cell differentiation degree and postoperative pathological T、 N staging.Results The levels of serum CEA and CYFRA21-1in patients are different when T、N stages and group numbers of metastasis lymphnodes are not same (P<0.05orP <0.01).Levels in patients of N2with multi-metastasis groups lymphnodes were significantly higher than those in patients of N1and N2with single-metastasis group lymphnode. The levels of serum NSE in patients of different T stages(Tl and T3) was significantly different (P<0.05),but there’s same level in patients with the different pathological N stages(P>0.05).Conclusions Preoperative detection of the serum concentration of CEA and CYFRA21-1has important clinical significance on the accurate judgment of tumor staging in patients with non-small cell lung cancer(particularly N staging), to help choose more reasonable treatments to patients.