Clinical Study On The Correlation Between TCM Syndrome Differentiation And International TNM Staging And Tumor Markers In 200 Patients With Primary Bronchial Lung Cancer

Objective1?By analyzing the literatures of traditional Chinese medicine or traditional Chinese medicine and western medicine in the study of lung cancer in recent 10 years,the status quo of TCM syndrome differentiation of lung cancer was analyzed statistically,and the distribution of common TCM syndromes in lung cancer was summarized,which provided an objective basis for further study of TCM syndrome differentiation of lung cancer.2 ? To explore the objective basis of microcosmic syndrome differentiation of Lung Cancer by studying the relationship between the primary lung cancer TCM Syndromes and TNM stage and its associated tumor markers(CEA,CA199,CA125,CA153,TSGF,SCC-Ag,NSE,CYFRA21-1,Pro GRP,VEGF),With a view to the diagnosis,treatment and prognosis of lung cancer to do the combination of chinese and western medicine.Methods1?Retrieved January 2007-November 2016 Wanfang database and the Chinese Journal Full-text Database(CNKI)included in the study of traditional Chinese medicine or integrated traditional Chinese and Western medicine in lung cancer literature,according to the literature into the standard and exclusion criteria for screening of lung cancer TCM syndrome differentiation Of the literature,by analyzing the number of TCM syndromes in the literature and the frequency of appear in the literature,summed up the distribution of common TCM syndromes of lung cancer.2?We divided 200 cases of primary bronchial lung cancer patients into qi-yin deficiency syndrome?qi deficiency and phlegm-dampness syndrome?qi stagnation and blood stasis syndrome?yin-asthenia pyretic toxicity syndrome?phlegm-heat cumber lung syndrome five types of syndromes;By detecting the expression of serum tumor markers in each group of patients with lung cancer analyzed the relationship between the TCM syndromes and TNM stage and tumor markers.Results1?According to the frequency of lung cancer TCM syndrome in the literature and the number of cases,combined with the ratio between the types of comparison,we can considered the common TCM syndromes of lung cancer are qi-yin deficiency syndrome?qi deficiency and phlegm-dampness syndrome?qi stagnation and blood stasis syndrome?yin-asthenia pyretic toxicity syndrome?phlegm-heat cumber lung syndrome?lung spleen deficiency syndrome.2?The relationship between TCM Syndromes of Lung Cancer and TNM Stage:it is significant difference between Syndromes of Lung Cancer and TNM Stage(P<0.01);There are significant difference in the TCM syndromes between the stage? and the stage?,the stage? and the stage?(P<0.01);It is no different in the TCM syndromes between the stage? and the stage?(P>0.05);Comparison of serum CEA in TCM syndromes of lung cancer:yin-asthenia pyretic toxicity syndrome>qi stagnation and blood stasis syndrome>qi-yin deficiency syndrome>qi deficiency and phlegm-dampness syndrome>phlegm-heat cumber lung syndrome,it is significant difference in yin-asthenia pyretic toxicity syndrome and qi deficiency and phlegm-dampness syndrome?yin-asthenia pyretic toxicity syndrome and phlegm-heat cumber lung syndrome(P<0.01);it is different in qi stagnation and blood stasis syndrome and qi deficiency and phlegm-dampness syndrome,qi stagnation and blood stasis syndrome and phlegm-heat cumber lung syndrome,qi-yin deficiency syndrome and yin-asthenia pyretic toxicity syndrome(P<0.05);Comparison of serum CA199 in TCM syndromes of lung cancer:qi stagnation and blood stasis syndrome>phlegm-heat cumber lung syndrome>qi deficiency and phlegm-dampness syndrome>yin-asthenia pyretic toxicity syndrome>qi-yin deficiency syndrome,it is significant difference in qi deficiency and phlegm-dampness syndrome and qi-yin deficiency syndrome,qi deficiency and phlegm-dampness syndrome and qi stagnation and blood stasis syndrome,qi-yin deficiency syndrome and qi stagnation and blood stasis syndrome,yin-asthenia pyretic toxicity syndrome and qi stagnation and blood stasis syndrome(P<0.01);Comparison of serum CA125 in TCM syndromes of lung cancer:yin-asthenia pyretic toxicity syndrome>phlegm-heat cumber lung syndrome>qi deficiency and phlegm-dampness syndrome>qi stagnation and blood stasis syndrome>qi-yin deficiency syndrome,it is significant difference in qi deficiency and phlegm-dampness syndrome and qi-yin deficiency syndrome(P<0.01);it is different in yin-asthenia pyretic toxicity syndrome and qi-yin deficiency syndrome(P<0.05);Comparison of serum CA153 in TCM syndromes of lung cancer:phlegm-heat cumber lung syndrome>qi-yin deficiency syndrome>qi deficiency and phlegm-dampness syndrome>qi stagnation and blood stasis syndrome>yin-asthenia pyretic toxicity syndrome,there are no difference in TCM syndromes of lung cancer(P>0.05);Comparison of serum TSGF in TCM syndromes of lung cancer:qi deficiency and phlegm-dampness syndrome>qi-yin deficiency syndrome>phlegm-heat cumber lung syndrome>yin-asthenia pyretic toxicity syndrome>qi stagnation and blood stasis syndrome,there are no difference in TCM syndromes of lung cancer(P>0.05);Comparison of serum SCCAg in TCM syndromes of lung cancer:qi-yin deficiency syndrome>qi deficiency and phlegm-dampness syndrome>phlegm-heat cumber lung syndrome>yin-asthenia pyretic toxicity syndrome>qi stagnation and blood stasis syndrome,it is significant difference in qi deficiency and phlegm-dampness syndrome and qi stagnation and blood stasis syndrome,qi-yin deficiency syndrome and yin-asthenia pyretic toxicity syndrome,qi-yin deficiency syndrome and qi stagnation and blood stasis syndrome(P<0.01);it is different in qi deficiency and phlegm-dampness syndrome and yin-asthenia pyretic toxicity syndrome(P<0.05);Comparison of serum CYFRA21-1 in TCM syndromes of lung cancer:qi deficiency and phlegm-dampness syndrome>qi stagnation and blood stasis syndrome>qi-yin deficiency syndrome>phlegm-heat cumber lung syndrome>yin-asthenia pyretic toxicity syndrome,it is significant difference in qi deficiency and phlegm-dampness syndrome and qi-yin deficiency syndrome,qi deficiency and phlegm-dampness syndrome andyin-asthenia pyretic toxicity syndrome(P<0.01);Comparison of serum NSE in TCM syndromes of lung cancer:qi-yin deficiency syndrome>qi deficiency and phlegm-dampness syndrome>qi stagnation and blood stasis syndrome>yin-asthenia pyretic toxicity syndrome>phlegm-heat cumber lung syndrome,it is significant difference in qi deficiency and phlegm-dampness syndrome and qi-yin deficiency syndrome,qi deficiency and phlegm-dampness syndrome and phlegm-heat cumber lung syndrome,qi-yin deficiency syndrome and yin-asthenia pyretic toxicity syndrome,qi-yin deficiency syndrome and qi stagnation and blood stasis syndrome,qi-yin deficiency syndrome and phlegm-heat cumber lung syndrome,qi stagnation and blood stasis syndrome and phlegm-heat cumber lung syndrome(P<0.01);it is different in yin-asthenia pyretic toxicity syndrome and phlegm-heat cumber lung syndrome(P<0.05);Comparison of serum ProGRP in TCM syndromes of lung cancer:qi stagnation and blood stasis syndrome>yin-asthenia pyretic toxicity syndrome>phlegm-heat cumber lung syndrome>qi deficiency and phlegm-dampness syndrome>qi-yin deficiency syndrome,there are no difference in TCM syndromes of lung cancer(P>0.05);Comparison of serum VEGF in TCM syndromes of lung cancer:qi deficiency and phlegm-dampness syndrome>phlegm-heat cumber lung syndrome>qi stagnation and blood stasis syndrome>qi-yin deficiency syndrome>yin-asthenia pyretic toxicity syndrome,it is different in qi deficiency and phlegm-dampness syndrome and qi-yin deficiency syndrome(P<0.05).Conclusions1?The common TCM syndromes of lung cancer are qi-yin deficiency syndrome?qi deficiency and phlegm-dampness syndrome?qi stagnation and blood stasis syndrome?yin-asthenia pyretic toxicity syndrome ? phlegm-heat cumber lung syndrome ? lung spleen deficiency syndrome.2?The lung cancer TCM syndrome differentiation and TNM staging have a certain correlation,TNM staging can be used as indicators of lung cancer microscopic syndrome.Lung cancer patients serum tumor markers CEA?CA199?CA125?SCC-Ag?NSE ? CYFRA21-1 ? VEGF levels TCM syndrome differentiation have a certain relevance,serum tumor marker can be considered as an assistant objective basis for the TCM syndrome type of lung cancer.