Research On Changes Of IL-1 And IL-6 Levels In Gingival Crevicular Fluid After Implant Restoration In Patients With Chronic Periodontitis

Objective: By observing the clinical effects within one year after dental implants as well as the changes in IL-1 and IL-6 levels found in patients with chronic periodontitis, the correlation between chronic periodontitis and peri-implantitis was explored, thereby providing a theoretical basis for the implant restoration of patients with chronic periodontitis. Methods: Twenty-eight implant dentures from 18 randomly selected patients with chronic periodontitis were divided into group A, and twenty implant dentures from 15 periodontally healthy patients were divided into group B. The modified plaque index(m PLI), modified sulcus bleeding index(m SBI), probing depth(PD) and marginal bone loss(MBL) volume were detected respectively in dentures from groups A and B after 1, 3, 6 and 12 months after implant restoration. The IL-1β and IL-6 contents in gingival crevicular fluid were detected using ELISA method. At the same time, record a year after the implant retention rate. The relevant experimental data was statistically analyzed using SPSS17.0 statistic software package. Results: The implant survival rates in two groups were 100% respectively within one year. Results of horizontal comparison: The differences in mPLI, MBL and IL-6 content in two groups started to be statistically significant at three month after implant restoration. No statistically significant differences in m SBI and PD were observed at 1 and 3 months after implant restoration, while statistically significant differences appeared at 6 months after implant restoration. Results of longitudinal comparison: 1. Inter-group comparison showed that there was no statistically significant difference in m PLI between the chronic periodontitis group and the periodontally healthy group considering their equal change magnitude of mPLI. 2. Inter-group comparison indicated that the difference in IL-1β content was statistically significant between the chronic periodontitis group and the periodontally healthy group,but their change magnitude of IL-1β content was identical. 3. In the chronic periodontitis group, the change magnitude of IL-1β content in the implant gingival crevicular fluid became higher than that in the periodontally healthy group since 3 months after implant restoration. 4. Pairwise comparison between groups suggested that statistically significant differences in m SBI, MBL and PD were observed from 6 months after implant restoration, with a higher change magnitude in the chronic periodontitis group than the periodontally healthy group. Conclusion: 1.The good short-term clinical efficacy was reported in chronic periodontitis patients with agomphiasis after implant restoration. 2. Implant patients with chronic periodontitis face a greater risk of suffering from peri-implantitis, which requires them to be more cautious when considering implant denture restoration. 3. After restoration by implant dentures, patients, especially those implant patients with chronic periodontitis, should pay special attention to cleaning and maintenance of implant dentures at early stage, which would contribute to the long-term success rate of implant dentures.