| Objective:Observing the level of serum uric acid (UA) in patients with acute cerebral infarction(ACI) and the ACI patients complicated with hypertension to investigate the relationship among them. And observing the effect of repetitive limb ischemic (RLI) on the level of serum UA and the degree of neural function defect on those indexes above to study the effect and possible pathophysiologic mechanism of RLI to the acute cerebral infarction.Methods:1.66 healthy persons as normal-control group and 74 patients with cerebral infarction as case group coincident with the diagnosis of acute cerebral infarction. A total 140 cases of patients match the inclusion and exclusion standard, and two groups were comparable in age and gender composition. By contrast research method, the case group were randomly divided into the case-control group (36cases) and RLI group(38 cases), two groups in age gender and severity of ill condition were comparable. The normal-control and case group were divided into hypertension group and non hypertension group on the basis of whether the patients of the two groups complicated with hypertension. In the normal-control group, there were 24 case in the hypertension group and 42 case in the non hypertension group. In the control group, there were 44 case in the hypertension group and 30 case in the non hypertension group. The age and gender composition were comparable among the groups.2. Collect the clinical data of the patients whether complicated with history of hypertension disease or not. Measured the blood pressure of the selected patients for three times not on the same day by mercury sphygmomanometer. Hitachi automatic biochemical analyzer,7600-110 and UA determination kit produced by Japan and optical pure medicine industrial plant type was used to measure the level of UA (μmol/L) by enzymic method.3. The changes of above parameters were recorded before and after treatment, as well as assessed degree of neural function defect with the National Institute of Health stroke scale (NIHSS).The first data (before treatment)were marked as "1"and the second date (after treatment)were marked as "2", and "1 mius 2" was marked as "D-value". Observation and record the untoward effect during RLI. In this study, SPSS 20.0 software was used for statistical analysis and the significance test of the bilateral level was less than 0.05 (P<0.05).Results:1. The case group levels of serum UA1 (339.750±92.480) were higher than the normal-control group levels of serum UA1 (303.952±76.129), the difference has statistically significance (P<0.05); The case group levels of serum UA2 (323.750±100.166) were higher than the normal-control group, the difference has not statistically significance; The case group levels of serum UA2 were lower than the levels of serum UA1, the difference has marked statistically significance (P<0.01). Hypertension positive rate (59.5%) in the case group were higher than hypertension positive rate (36.4%) in the normal-control group, the difference has marked statistically significance (P<0.01).2. In the normal-control group, the level of serum UA (313.304±66.984) in the hypertension group were higher than the level of serum UA (298.570±81.249) in the non hypertension group, the difference has not statistically significance.3. In the case group, the level of serum UA1 (360.909±87.000) in hypertension group were higher than the level of serum UA1 (306.500±92.518) in non hypertension group, the difference has marked statistically significance (P<0.01). The level of serum UA2 (324.909±86.267) and serum UA D-value (42.364±59.957) in hypertension group were higher than The level of serum UA2 (321.200±129.082) and serum UA D-value (11.214±67.374) in non hypertension group, the difference has not statistically significance.4. The NIHSS1 scores has no significantly difference in case group (3.000±2.070) and RLI group (3.290±1.814). The NIHSS2 scores (2.670±1.957) in case group were lower than the NIHSS1 scores, the difference has not statistically significance. The NIHSS2 scores (2.450±1.766) in RLI group were lower than the NIHSS1 scores, the difference has marked statistically significance (P<0.01) and the NIHSS D-value (0.820±0.834) in RLI group were bigger than the NIHSS D-value (0.330±0.956) in case group, the difference has statistically significance (P<0.05).5. The difference of the level of serum UA1 in the case-control group and RLI group (357.714±98.083,322.830±84.617) has not statistically significance. The level of serum UA2 (350.826±109.220) in the case-control group were lower than the level of UA1, the difference has not statistically. significance; the level of serum UA2 (298.840±85.816) in the RLI group reduction liken to the level of UA1, the difference has marked statistically significance (P<0.01); the level of serum UA D-value (53.040±47.280) in RLI group were bigger than the level of UA D-value (10.409±71.935), the difference has marked statistically significance (P<0.01); The difference of the level of serum UA2 in the case-control group and RLI group has not statistically significance..6. During the process of RLI treatment, there were 34 patients felt numbness of the compressive limb. At the same time, there were 8 case felt ache and 2 case appeared punctuate hemorrhage in the compressive limb. All of the felling of numbness and ache was disappeared within 5 minutes after the treatment and the punctuate hemorrhage was disappeared within 1 day after all the treatment, had no other complaints.Conclusion:1. The level of serum UA was increased significantly in patients with acute cerebral infarction, and with obvious dynamic change. It promoted that UA might take part in the pathophysiologic mechanism of the acute cerebral infarction.2. The level of serum UA in patients of acute cerebral infarction complicated with hypertension is higher than the patients without hypertension, It promoted that intrigue interaction among them。3. RLI could decrease the level of serum UA and degree of neural function defect significantly, security, It indicated that RLI might improve the prognosis of acute cerebral infarction, may be a safe and effective method for the treatment. |
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