| Objective: The present research aims to explore the effects of the acute cerebral infarction, the severity on admission, the relapse, the status at discharge and the prognosis on uric acid. And investigate the role of the uric acid in acute cerebral infarction. Therefore, how to control the concentration of the uric acid to decrease the cerebral infarction morbidity, the recurrence rate, the severity of illness to lay the foundation for preventing the primary and compliance behavior of the cerebral infarction, for improving the prognosis of the cerebral infarction, and for working out the treatment will be discussed.Method: We use a retrospective case-control study.1. Use homemade questionnaire way.The obserevr group is made up of 502 cases in total because of the acute cerebral infarction from March 2013 to October 2013 from the Neurology of North Sichuan Medical College Affiliated Hospital(age, sex, blood uric acid, blood fat, blood glucose, blood pressure and so forth), NIHSS on discharge, MRS, TOAST and other biochemical index. In contrast, they collected 486 cases of non-cerebral infarction patients in the hospital in the same period as a compared group.2. Analysis which is based on the basic information of the obserevr group and the controlled group is conducted. The acute cerebral infarction patients are divided into three groups according to the NIHSS on admission, the attack frequency, and the prognosis on discharge.(1)Compare the basic information of the acute cerebral infarction group with the non-cerebral infarction group.(2)Divide into groups according to the NIHSS on admission.(3)Divide into groups according to the attack frequency. The first attack time is the acute cerebral infarction of the first group. The second or several attack times are the acute cerebral infarction of the recrudescence groups.(4)Divide into groups according to the progress on discharge. Rate of 502 cases of the acute cerebral infarction patients on NIHSS on discharge, the scores of the NIHSS on discharge minus the scores of the same patient’s NIHSS on admission as outcome scores. Divide into the curative effect of groups according that the outcome scores combine with the MRS: the nearly recovery: the scores drop 91% to 100% because of function deficit. The disable degree is zero level. The significant progress: the scores decline from 46% to 90% because of the function deficit. The disable degree is one to three levels because of the function deficit. Progress: the scores drop 18% to 45% because of the function deficit----Unchanged. Scores decline about 17%---deterioration. The scores increase by more than 18% because of the function deficit---death. The curative effect of the nearly recovery, the significant progress and the progress is the good prognosis groups on discharge. The curative effect of the unchanged, the deterioration and the death is the poor prognosis groups on discharge.Result: 1. The cerebral infarction groups(502 cases) compare with the non-cerebral infarction groups(486 cases) by the single factor: Age, UA, hyperuricemia rate, TG, LDL-C, Blood type with semi finished glycogen.There was a positive correlation between the increase the content of the uric acid and the acute cerebral infarction. Differences are statistically significant.2. The primary cerebral infarction groups(396 cases) compare with the recrudescence cerebral infarction( 106 cases) by the single factor. Differences are statistically in UA, hyperuricemia rate, Age, Cholesterol, Blood sugar, Hypertension history. There was a positive correlation between the increase the content of the uric acid and the recurrent cerebral infarction.3.The minor cerebral infarction groups(239 cases) compare with the serious cerebral infarction(263 cases) by the single factor. Increase the content of the uric acid shows a negative relation with the severity of the cerebral infarction on admission. However, differences are not statistically significant. Hyperuricemia rate between the two groups have statistically significant.4.The good prognosis of cerebral infarction groups( 440 cases) compare with the poor prognosis of cerebral infarction groups(62 cases) by the single factor. There was a positive correlation between the increase the content of the uric acid and the good prognosis of cerebral infarction. Differences are not statistically significant. Hyperuricemia rate between the two groups have statistically significant.Conclusion: 1. The ihyperuricemia is one of the dangerous factors for the cerebral infarction.2. The hyperuricemia is one of the dangerous factors for the recrudescence cerebral infarction.3. There is no correlation between the increase the content of the uric acid and the severity of the acute cerebral infarction patients on admission.4. There is positive correlation between the increasing of the uric acid and the prognosis of the acute cerebral infarction on discharge.5. The administration of exogenous uric acid may play a positive role in improving the prognosis in the acute phase of cerebral infarction. |
PDF Full Text Request