Gu-Ci-Xiao Mixture Treatment Knee Elimination Bi Disease Of Kidney Deficiency Syndrome In Clinical Research

Objective:The effective method to explore the clinical treatment of KOA is an important task at present. Clinical curative effect observation of this topic by Gucixiao mixture in treating KOA of human serum and the biochemical indexes of traditional Chinese medicine, to more effectively and safely applied to the treatment of KOA to provide the basis.Methods:This topic selected 40 patients with knee osteoarthritis, hospital diagnosis after clear all cases in the treatment of early in the morning on an empty stomach before venous sampling 5 ml, heparin anticoagulation, used for determination of SOD and content of NO and TNF - a, the SOD determination by the methods of xanthine oxidase (hydroxylamine method), NO enzymatic determination of nitrate reduction, TNF - a by using enzyme-linked immunosorbent determination, operation according to the determination of kit built biological engineering research institute (nanjing) production instructions. At the same time on VAS score and knee joint HSS score. And oral bone spur mixture, 40 ml each time, 3 times a day, oral after the meal, a total of just four weeks, a total of 14 bottles, 4 weeks after treatment and 4 weeks after the drug was stopped, and with the same method of blood and reiteration VAS score and review of the knee joint HSS score. Through the VAS pain score and the measurement of knee joint HSS score and patients’serum SOD, NO and TNF - a change in value, to explore the bone spur mixture on the curative effect of knee osteoarthritis.Results:1 the visual analogue scale (VAS):oral Gucixiao mixture, compared with before treatment,40 patients symptoms improved, 4 weeks of medication, stop drug 4weeks compared with before treatment there were significant differences were statistically significant (P<0.01).2 HSS knee joint score: oral Gucixiao mixture, 40 patients with knee HSS score than before treatment improved, 4 weeks of medication, stop drug 4 weeks compared with before treatment there were significant differences were statistically significant(P<0.01).3 biochemical indicators:oral Gucixiao mixture, 40 patients of SOD in serumincreased numerical than before treatment, NO and TNF-a values than before treatment were decreased,4 weeks of medication, stop drug 4 weeks compared with before treatment there were significant differences were statistically significant(P<0.01).Conclusion:Gucixiao mixture can effectively reduce KOA in patients with pain and other clinical symptoms, improve the function of knee joint, the increase of SOD content in serum,decreased NO and TNF-a content, and no significant adverse reactions, can effectively, safely control KOA.