96 Cases Of Clinical Characteristics And Treatment Of Facial Hormone-dependent Dermatitis

Objective: Analysis the clinical characteristics of hormone-dependent facial dermatitis, compare the curative effect of different treatments for hormone-dependent facial dermatitis, explore the effective treatment.Methods: Collect the hospital dermatology clinic during January 2012- December 2014 with "hormone-dependent facial dermatitis of 96 cases of patients, through collecting detailed medical history, record the clinical manifestations of the clinical characteristics and curative effect were retrospectively analyzed. The 29 patients only with 0.03% tacrolimus ointment treatment method(1) : in the morning and one for external use; 33 cases by using 0.03% tacrolimus ointment combined winona tramal moisturizing cream treatment method(2) : 2 times a day(0.03% tacrolimus ointment for external use only half an hour after besmear outside winona tramal moisturizer); 34 exception with 0.03% tacrolimus ointment combination of recombinant human epidermal growth factor gel treatment method(3) : 2 times a day(0.03% tacrolimus ointment for external use only half an hour after external use of recombinant human epidermal growth factor gel). Three groups of treatment, 1 months after discontinuation of treatment 2 weeks, 4 weeks and 2 weeks follow-up observation.Results: Of the 96 patients with hormone-dependent facial dermatitis, 51 cases caused by external preparation(53.13%), 45 cases(46.87%) caused by cosmet ics. Common in women, most(35.29%), followed by self-employed or unemployed(27.25%); Cultural degree is given priority to with junior middle school and primary school, accounted for 43.14% and 23.53% respectively; Purchase way in private clinics(5.10%), most of dermatology buy medicines at least(5.89%); Glucocorticoid effective external preparation of hormone(52.94%), the effect of hormone(45.10%), inefficient hormone(1.96%). In hormone-dependent facial caused by cosmetics, staff(51.11%), followed by most rural patients(26.67%). Protect skin to taste in white(55.56%), spot(31.11%). Treatment 2 weeks, the results of the three methods integral improvement has no obvious difference(P > 0.05), efficient no statistical significance(P > 0.05). Treatment of 4 weeks, tacrolimus ointment combined winona tramal integral improve moisturizing cream group was obviously better than tacrolimus ointment alone group(P < 0.05), significantly higher than the efficient use of tacrolimus ointment group(P < 0.05); Joint tacrolimus ointment for external use integral improvement of recombinant human epidermal growth factor gel group was obviously better than tacrolimus ointment alone group(P < 0.05); Significantly higher than the efficient use of tacrolimus ointment group(P < 0.05); Joint topical winona tramal moisturizing cream with recombinant human epidermal growth factor gel group(P > 0.05). 2 weeks after the drug was stopped, tacrolimus ointment combined treatment group(joint winona tramal moisturizing cream or recombinant human epidermal growth factor gel) integral improvement than tacrolimus ointment group(P < 0.05), efficient than tacrolimus ointment alone group(P < 0.05); Tacrolimus ointment combined winona tramal moisturizing cream group with tacrolimus ointment recombinant human epidermal growth factor group integral improved(P > 0.05), and efficient no significant statistical difference(P > 0.05).Conclusion: Hormone-dependent facial dermatitis patients, give priority to with young women, topical drugs and cosmetics to two great causes. Glucocorticoid topical preparations were varied, use for a long time; Hormone-dependent facial dermatitis induced by cosmetics has its particularity, hormone secretiveness, way to purchase and product diversity, a large proportion in treating hormone-dependent facial dermatitis. Three approaches to therapy in treating hormone-dependent facial dermatitis clinical symptoms were improved. Between treatment 2 weeks treatment, three methods; Treatment of 4 weeks, and 2 weeks after the drug was stopped, tacrolimus ointment combined winona tramal moisturizing cream or recombinant human epidermal growth factor gel in the treatment of hormone-dependent facial dermatitis curative effect is superior to pure use of tacrolimus ointment, tacrolimus ointment combined winona tramal moisturizing cream with tacrolimus ointment effect of recombinant human epidermal growth factor gel.