Clinical Study203Cases Of EH Circadian Rhythm Changes

Objective: The203cases of essential hypertension (Essential hypertension, EH) weredivided into non-dipper group and dipper group，two groups were compared in ventricularremodeling, differences of cardiovascular complications, and to explore the relationshipbetween gender, age, smoking,the different biochemical markers and circadian rhythm,analysis of ambulatory blood pressure differences between two different parameters anddifferent age groups ambulatory blood pressure parameters. To explore the relationshipbetween circadian rhythm disorders and cardiovascular disease, and better control of highblood pressure, eliminate circadian rhythm disorders, reduce cardiovascular andcerebrovascular damage target organs provide a new theoretical basis.Methods: August2012-2014in February Wannan Medical College Yijishan inpatienthospital I was diagnosed203cases of patients with essential hypertension, in which thenon-dipper group162cases, dipper group41cases，age≥30years, duration of at leastone month. Except by history taking and examination related secondary hypertension,diabetes mellitus, hyperthyroidism or hypothyroidism, severe anemia, aorticregurgitation, congenital heart disease, cardiomyopathy and other causes severe liver,impaired renal function. All patients were then divided into groups of young,middle-aged group, age group and the very elderly group. Comparison group ofnon-dipper and dipper group differences occur ventricular remodeling and cardiovascularcomplications, discuss sex, the relationship between age, smoking, and variousbiochemical markers of circadian rhythm, dynamic analysis of two different blood parameters and different age groups differences in ambulatory blood pressure parameters.Application SPSS17.0statistical software for statistical analysis.Results: The proportion of cardiovascular complications in non-dipper group, LVMI andage, Bun higher than the dipper group, the difference was statistically significant;smoking rates in non-dipper group, TC, TG, Cr and IVS, LVPWT, LVM is higher thanthe dipper group, the difference was statistically significant; sex, HDL-C, LDL-C, GLUand LVEDD and dipper group was not statistically significant than the differences. Veryelderly group compared24hASBP,24hADBP, nSBPV, nDBPV difference wasstatistically significant (P <0.01or0.05) and the young group; elderly and middle-agedgroup group24hASBP,24hADBP,24hSBPV, dSBPV difference was statisticallysignificant (P <0.01or0.05); older group and middle-aged group24hASBP,24hADBP,24hSBPV difference was statistically significant (P <0.01or0.05); elderly group and theyoung group24hASBP, nSBPV difference was statistically significant (P <0.05).Conclusion: Non-dipper hypertensive cardiovascular and cerebrovascular complicationsand left ventricular remodeling was significantly higher than dipper hypertensive, Non-dipper hypertensive target organ damage heavier; age, smoking, dyslipidemia, Bun andCr on blood pressure circadian influence; ambulatory blood pressure monitoringparameters related parameters for clinical judgment systolic non-dipper hypertension andhypertensive target organ damage has important value.