Correlation Study Between Ambulatory Arterial Stiffness Index And Target Organ Damage In Hypertension

Objective:The damage of target organs caused by long-term hypertension is the main cause of its disability and death.Therefore,the protection of important target organs is more important in the prevention and treatment of hypertension.How to evaluate the damage of target organs caused by hypertension early by clinical simple and reliable monitoring methods is a very meaningful topic in clinical practice.In order to explore the correlation between dynamic arteriosclerosis index(AASI)and the damage of target organs of hypertension,We studied the relationship between the renal function damage and left ventricular hypertrophy in 249 hypertensive patients and the dynamic arteriosclerosis index.At the same time,we analyzed other risk factors affecting arteriosclerosis,with a view to evaluating the significance of AASI monitoring in the early injury of target organs.To provide theoretical basis and clinical guidance for finding reliable,cheap,early,convenient and novel auxiliary prediction indicators of early target organ injury in hypertensive patients.Methods:Patients with hypertension who were hospitalized in the Department of Cardiovascular Medicine,China-Japan Friendship Hospital of Jilin University between October 2019 and September 2021 were retrospectively selected.After screening based on the inclusion and exclusion criteria,a total of 249 subjects including 128 females and 121 males were included.Record basic information such as age,gender,height,weight,diabetes and other previous medical history,monitor24-hour ambulatory blood pressure,including waking time and sleep time blood pressure,record sleep time,and calculate AASI.AASI calculation: 24 h diastolic blood pressure is the ordinate,24 h systolic blood pressure is the abscissa,and the regression slope is calculated β,AASI=1-regression slope β。 At the same time,serum creatinine,urine protein,fasting blood glucose,blood lipids and other laboratory indicators and LA,RV,IVS,LVD,LVPW and other cardiac color Doppler ultrasound related indicators were collected.Results:1.The 24-hour average diastolic blood pressure,24-hour average pulse,BMI,and creatinine clearance rate of the AASI high-level group were lower than those of the AASI low-level group,and the age of the AASI high-level group was older than that of the AASI low-level group,and the above differences were statistically significant(P<0.05).2.There was a negative correlation between AASI and Ccr in hypertensive patients,with statistical significance(P<0.05).3.Age,BMI and AASI of hypertensive patients were the main influencing factors of renal damage(P<0.05).However,gender,24-hour mean systolic blood pressure,24-hour mean diastolic blood pressure,24-hour mean pulse,fasting blood glucose and blood lipid level had no significant impact on renal damage in hypertensive patients(P>0.05).4.There was a positive correlation between AASI and left ventricular mass index(LVMI)in patients with hypertension(P<0.05).5.The 24-hour mean systolic blood pressure of hypertensive patients was the main influencing factor of left ventricular hypertrophy(P<0.05).However,the effects of 24-hour mean diastolic pressure,24-hour mean pulse,age,BMI and AASI on left ventricular hypertrophy in hypertensive patients were not statistically significant(P>0.05).Conclusion:1.For patients with essential hypertension,the age of high AASI level is relatively large,and with the increase of age,the greater the risk of renal damage.2.The AASI and Ccr of patients with essential hypertension are significantly negatively correlated(P<0.05).At the same time,AASI is a risk factor for renal damage,AASI can be used as an assessment index for renal damage in patients with essential hypertension.3.AASI and LVMI in patients with essential hypertension have a weak positive correlation(P<0.05).However,compared with AASI,the level of 24-hour systolic blood pressure may have a greater impact on left ventricular hypertrophy.4.AASI,as an indicator that can reflect the condition of arteriosclerosis,has a convenient examination method and is conducive to clinical application and promotion.