The Corelations Between Blood Pressure Circadian Rhythm And Plasma Apelin-36 Adiponectin Levels In Essential Hypertension Patients

Objective:To explore the relations between the 24 hour ambulatory blood pressure variability and plasma adiponectin levels in essential hypertension patients.Methods:Totally 224 EH cases were divided into Dipper and Non-dipper hypertensive groups according to their 24h ambulatory blood pressure monitoring (24hABPM);Fasting venous blood was drawn to detect the plasma adiponectin, fasting insulin (FINS), fasting plasma glucose (FPG);body height and weight were measured, calculating body mass index(BMI)and insulin resistance index(IRI).Results:(1)The plasma adiponectin level in the Dipper hypertensive groups was significantly higher than that in the Non-dipper hypertensive groups (P<0.01). (2) The body mass index(BMI) and insulin resistance index(IRI) in the Dipper hypertensive groups was lower than that in the Non-dipper hypertensive groups (P<0.05). (3)The plasma adiponectin level was negatively correlated with 24h systolic blood pressure (SBP), BMI, IRI (P<0.05or0.01)Conclusions:The plasma adiponectin level was correlated with blood pressure circadian rhythm, and the plasma adiponectin level in Non-dipper hypertensive patients was lower than that in Dipper hypertensive patients.Objective: To explore the correlation between the 24-hour average blood pressure levels in essential hypertension (EH) and the plasma Apelin-36 levels. To explore the relations between the 24 hour ambulatory blood pressure variability and plasma Apelin-36 levels in essential hypertension patients.Methods:224EH cases was selected for the subjects from the 1st June 2009 to the 1st June 2010.224 EH cases were divided into Dipper and Non-dipper hypertensive groups according to their 24h ambulatory blood pressure monitoring (24hABPM);and 144 normal cases were selected for the control group. Fasting venous blood was drawn to detect the plasma Apelin-36 levels by radioimmunoassay (RIA).Results:(1)The plasma Apelin-36 levels were 24.65±4.10pmol/l in the control group and 20.81±4.98 pmol/l in the EH group. There was significant statistical difference between the two groups (P<0.01. (2) In the EH group, the plasma Apelin-36 levels were negatively correlated with 24-hour average systolic blood pressure, day average systolic blood pressure and night average systolic blood pressure. (3) The plasma Apelin-36 levels were 23.37±4.50 pmol/l in the Dipper hypertensive groups and 18.45±4.08 pmol/l in the Non-dipper hypertensive groups. The plasma Apelin-36 level in the Dipper hypertensive groups was significantly higher than that in the Non-dipper hypertensive groups (P<0.01).Conclusions:The plasma Apelin-36 levels in EH group were significantly lower than that in the control group, and the higher of the 24-hour levels and 24-hour average blood pressure. The plasma Apelin-36 level was correlated with blood pressure circadian rhythm, and the plasma Apelin-36 level in Non-dipper hypertensive patients was lower than that in Dipper hypertensive patients.