The Effects Of Common Risk Factors For Vascular Cognitive Impairment With No Dementia

Objective:To explore the effects and characteristics of vascular cognitiveimpairment without dementia in cognitive function with clinical commonrisk factors.Methods:The patients come from our department of neurology in China-JapanUnion Hospital of Jilin University who have vascular cognitiveimpairment with no dementia(VCIND)treatment546cases from January2013to January2015,male294cases,females252cases,aged from40to82years old. All the subjects are inspected the fasting bloodglucose,blood pressure,blood lipid,homo cysteine,electrocar-diogram,neck vessels colour to exceed,Hachinski ischemia scale(HIS), Montrealcognitive assessment scale(MoCA).patients with one or more of thefollowing risk factors:hypertension,diabetes,hyperlipidemia, high homocysteine levels,heart disea se,carotid stenosis,smoking, obesity,etc. Hypertension,diabetes,hyperlipidemia are the highest proportion of risk factors,respectively34.62%,34.80%,32.78%,according to the different with thesethree risk factors,the patients are divided into the following sevengroups(40cases per each group):group A:pure hypertension group, groupB:pure diabetes group, group C:pure hyperlipidemia group,groupD:hypertention+diabetes group,group E:diabetes+hyperlipidemiagroup,group F:hypertention+diabetes+hyperlipidemia group.Evaluate,compare and analyze the differences among the groups in all areas ofcognitive damage according to the MoCA. Results:Through statistical analysis,high blood pressure,high lipids, diabetesare the highest proportion of risk factors in VCIND for the most commonrisk factors. MoCA score of Groups comparison:D,E,F,G group ofMoCA score was lower than that in group A,B,C,the difference wasstatistically significant(P＜0.05).Group G MoCA score lower than D,E,Fgroup,P＜0.05,with statistical significance.Single risk factor:A,B,C groupcompare the influence of cognitive domain:in terms of visual spaceexecutive function score group B lower than group A and group C(P＜0.05);in terms of attention score group A lower than group B and groupC(P＜0.05);group A and group C in memory score lower than group B(P＜0.05).Double factors group:D,E,F group in comparison in the field ofcognition:in terms of memory score group F lower than group D,E(P＜0.05);in terms of visual space executive function score group D lowerthan group E,F(P＜0.05);group D,F score lower than group E in note(P＜0.05).Double factors in the cognitive domain scores compared with singlefactor group:group D in terms of visual space executive function scorewas lower than that in group A,B,C,group E was lower than group A andC,P＜0.05,statistically significant;group D and F lower than group B,C,P＜0.05,statistically significant;In terms of memory group D,E score lowerthan group B,group F lower than group A,B,C,P＜0.05,statisticallysignificant.There kind of risk factors in the field of cognitive scorecompared with other risk factor group:in terms of visual spaceexecutive,attention function group G was significantly lower than groupA,B,C,D,E,F(P＜0.05),statistically significant;in terms of memory groupF,G lower than group A,B,C,D,E(P＜0.05),with statistical significance. Conclusion:1.Hypertention,diabetes and high lipid are the most common riskfactors in VCIND.2.The more risk factors,the more serious the damage of cognitivefunction.3. To compare the influence of cognitive domain in patients withVCIND with single risk factor:hypertention tend to attention andmemory;diabetes tend to visual space executive function;high lipid tendto memory.4.There had a greater influence on the visual space、 executive andattention function when hypertention and diabetes coexist,hypertentionand high lipid,more influence on memory.5.Three kinds of risk factors coexist increased the damage of thevisual space executive and attention function.