Association Between Different Lipid Ratios And Diabetes In Chinese Adults With H-type Hypertension

Background:Previous studies have shown that lipid ratios [total cholesterol(TC)/high-density,lipoprotein cholesterol(HDL-C),atherogenic index of plasma(AIP,lg[triglyceride(TG)/HDL-C]),low-density lipoprotein cholesterol(LDL-C)/HDLC,non-HDL-C/HDL-C] were associated with the risk of diabetes in non-hypertension population.However,the relationship between different lipid ratios and diabetes is unclear in the H-type hypertension population.The purpose of this study is to investigate the relationship between lipid ratios and diabetes in Chinese adults with H-type hypertension,and to compare different lipid ratios with the ability to predict diabetes.Methods:The current study included 13,581 H-type hypertension participants from the China hypertension registry study.Multivariate logistic regression analysis were used to assess the association between different lipid ratios and diabetes.In addition,we visually observed the dose-response relationship between different blood lipid ratios and diabetes through smooth curve fitting.Finally,the area under the receiver operating characteristic(ROC)curve(AUC)was used to compare the ability of different lipid ratio indexes to predict diabetes.Results:The overall incidence of diabetes in the study population was 17.8%,and 41.0%of these diabetic patients were unaware of their diabetes status.All lipid ratios(TC/HDL-C,AIP,LDL-C/HDL-C,and non-HDL-C/HDL-C)were positively and independently associated with diabetes.In the fully adjusted model,AIP manifested the largest ORs of diabetes(OR:2.84;95%CI:2.37-3.41).However,the fully adjusted ORs(95%CI)of TC/HDL-C,LDL-C/HDL-C and non-HDL-C/HDL-C ratio was only1.34(1.27,1.43),1.40(1.29,1.51),1.42(1.35,1.50),respectively.From the smooth curve fitting graph,it could be seen that all blood lipid ratios(TC/HDL-C,AIP,LDL-C/HDL-C,and Non-HDL-C/HDL-C)were independently linearly correlated with diabetes.Comparing the area under receiver-operating characteristic curve(AUC),we found that AIP had the stronger ability to identify diabetes.Conclusions:All lipid ratios(TC/HDL-C,AIP,LDL-C/HDL-C,and non-HDL-C/HDL-C)were independently and positively correlated with the risk of diabetes in the Chinese population with H-type hypertension.Compared with other lipid ratios(TC/HDL-C,LDL-C/HDL-C,and non-HDL-C/HDL-C),AIP was superior in discriminating diabetes.