| ObjectiveDiabetes mellitus (Diabetes Mellitus, DM) is a kind of sugar metabolism disorder as the main feature of the disease. One of the most common is the type 2 diabetes mellitus (Type 2 diabetes mellitus, T2DM). The pathological features of its main performance for insulin resistance and (or) insulin deficiency or absence. Diabetes is a lifelong disease, with its complications, morbidity, disability rate higher hazards to human health, the study treatment of it is gradually deepened, prospective study of traditional Chinese medicine on diabetes is generally carried out. My tutor according to the understanding and treatment of diabetes disease doctors in past dynasties, combined with their own clinical observation and treatment for diabetes, syndrome characteristics of the late two deficiency of yin and Yang, with warming kidney, spleen dampness, promoting blood circulation and removing blood stasis as the principle, the use of Jinkui Shenqi Pill modified decoction plus minus treatment had a good curative effect. This topic is for the purpose of clinical efficacy and safety of preliminary evaluation of tutors by "Jinkui Shenqi Pill, lay the foundation for studying the classical prescriptions in the treatment of type 2 diabetes mellitus.MethodsThis research selects the type of deficiency of yin and Yang in two type 2 diabetic patients as the research object, the test was performed according to a prospective randomized control principle, a simple random grouping according to 90 cases of test group and selection of control relationship between composition 1:1 eligible patients, including 45 cases of treatment group,45 cases in the control group. Control group with oral administration of repaglinide and metformin tablets, according to blood glucose changes to adjust the dosage, treatment group on the basis of the control group and with Jingui Shenqi pills pills for oral decoction, a daily agent and cycle in the two groups for 3 months.Results1.Before and after treatment in the blood sugar level (fasting blood glucose, postprandial 2h plasma glucose, glycated hemoglobin) There was a significant difference (P<0.01), there was significant; blood glucose levels after treatment between groups and between groups glucose Comparing the differences, it was different (P<0.05), with a statistically significant improvement in glucose metabolism in the treatment group than the control group.2. Two glucose efficacy evaluation, the control group of 45 patients, shedding three cases, the total efficiency of 83.33%; the treatment group of 45 patients, shedding five cases, the total effective rate was 92.5%; the total efficiency of the treatment group than the control group, with statistically significant (P<0.05).3. Two groups of patients before and after total cholesterol, are more significant in the triglyceride group (P<0.05); after treatment, the difference in total cholesterol in the control group and the treatment group, the difference was not statistically significant (P> 0.05); the control group and the treatment group difference triglycerides, the difference was not statistically significant (P> 0.05), still can not explain the effect of the treatment group lower total cholesterol and triglyceride levels than the control group.4. Before and after treatment syndromes total score were significantly different (P<0.01), the treatment group than the control group; in particular, the treatment group after treatment dry mouth and throat, five upset hot, waist and knees, nocturia improve these three symptoms, compared with the control group, with statistical significance (P<0.05).5. Compare the efficacy of clinical symptoms between the two groups, the control group of 45 patients, shedding 3 cases, total effective rate was 71.43%; the treatment group of 45 patients, the total effective rate was 92.50%; total effective rate difference was statistically significant (P<0.05).6, Jingguishenqi pill found no adverse reactions throughout the course of treatment.ConclusionJinkui Shenqi Pill has a certain improving effect for the treatment of Yin Yang and two deficiency of blood glucose in patients with type 2 diabetes, can reduce glycated hemoglobin, in terms of TCM symptoms of yin and yang deficiency two, especially for the five upset hot, Yaoxisuanruan, night urination and other symptoms have a significant role in improving the. |
