Clinical Analysis Of The Effect Of Asphyxia On Newborns’ Serum Level Of Bilirubin

Objective: To explore potential factors that may have influence on theserum level of bilirubin, and discuss the clinical significance of serumbilirubin level in newborns with asphyxia.Methods: Clinical data of197cases were analyzed retrospectively, all ofwhom were admitted into neonatal ward of Children’s Hospital ofChongqing Medical University since January2013to December2013andwere in accordance with the inclusive criteria. Neonates were devided intothree groups, with70cases in control group,66cases in mild asphyxiagroup and61cases in severe asphyxia group. Then compared each group’sserum level of bilirubin and described its dynamic changing trend.Results:1. Comparison of distribution of the regionalization of serumbilirubin level’s risk degree in terms of the degree of asphyxia: controlgroup and severe asphyxia group were similarly dominated by low riskzone and low intermediate risk zone, while mild asphyxia group was byhigh intermediate risk zone.2. Comparison of distribution of asphyxia’sdegree in terms of the regionalization of serum bilirubin level’s risk degree:low risk zone was dominated by neonates in mild asphyxia group andsevere asphyxia group; low intermediate risk zone was dominated byneonates in control group and severe asphyxia group; high risk zone wasdominated by neonates in mild asphyxia group and control group; while inhigh intermediate risk zone the three groups were evenly distributed.3.Global evaluation of three groups’ changing trend of serum bilirubin level:For control group the serum bilirubin level ranked in the middle, fluctuating recurrently; for mild asphyxia group the serum bilirubin levelwas relatively high, changing slowly; and for severe asphyxia group, theserum bilirubin level was relatively low with a changing trend of varyingslowly and steady in earlier period while faster and sharply in later period.Conclusion:1. Newborns’ serum bilirubin level is affected by manyfactors.2. Effects of neonatal asphyxia on bilirubin metabolism manifest asthe increasement of bilirubin（irritably increased generation, poor ablility oftransformation）and the decreasement of bilirubin due to depletion inantioxident activity. Moreover, the latter one becomes more remarkablewhen asphyxia aggravates.3. Medical interventions and progresses inmeasuring method of bilirubin have effects on the specific measured valuesof serum bilirubin level to a certain degree.4. Neonatal serum level ofbilirubin is useful in indirect evaluation of the degree of asphyxia.5. Activeintervention is still needed in neonatal hyperbilirubinemia after asphyxia.