The PCT In Auxiliary Diagnosis Value Of Neonates With Asphyxia And Infection

Objective:To study the value of the diagnosis of asphyxia newborn infection with the serum procalcitonin (PCT)。Method:totally120cases were included according to the hospital diagnosis.which were divided into two groups, infection group and observation group that without infection,24cases with infection of asphyxia newborn as case group,96cases of asphyxia newborn without infection as control group, Full term in75cases of premature infants45cases;70cases of male, female50cases;Infection group includes3cases blood culture positive for children (2cases of e. coli.1cases of hemolytic staphylococci),21cases for12～48h after peripheral blood CRP positive, including9cases of bacterial pneumonia, purulent meningitis in2cases, infection caused by hard swollen (3cases), necrotizing enterocolitis with peritonitis in1case, pustular sore (3cases), umbilical infection in2cases, cytomegalovirus infection in1case; Neonatal infection diagnosis of day age infection group were48h after birth, those who Apgar scoring less than7points, conforms to the Chinese medical association of pediatrics branch of neonatal asphyxia diagnosis standards, each birth was detected in12to48hours after,and in all group blood leucocyte count (WBC) and c-reactive protein (CRP), procalcitonin(PCT) were detected, The electrochemical luminescence method is adopted to detect the contents of serum PCT, serum CRP content is determined by immune turbidimetry, USES the blood cell analyzer determination of white blood cell count.Results:The PCT test positive rate in neonatals of Asphyxia co-infection is higher than without infection group (simple asphyxia group), the difference was statistically significant (P<0.05). Asphyxia newborn whether merge infection, the WBC, elevated CRP can be characterized by, or within the normal range. The WBC joint CRP detection and detection of PCT in combination with one of two methods to detect the positive comparison, the difference was statistically significant. Conclusion:1. the expression level of PCT in the neonatal period are not affected by the mom’s level of PCT or by the factors of acute inflammatory reaction, but can have a close correlation between the severity of the pathogenic bacteria infection.2.This research will be joint detection of serum PCT application in the clinical diagnosis of neonatal asphyxia with infection, the results show that the joint detection sensitivity, specific, positive predictive value, negative predictive value and index were higher than single detection, and found that the serum PCT level in children with asphyxia co-infection group was obviously higher than the control group. therefore, PCT Joint the WBC,and CRP detection can improve the neonatal asphyxia co-infection diagnostic sensitivity and specific degrees.