Changes Of The Concentration Of Serum Neuron Specific Enolase And Total Bilirubin In Neonatal Asphyxia And Their Clinical Significance

Objective: By observing the concentration change of serum neuron specificenolase (NSE) in 24,72 hours after birth in asphyxia neonatorum, and detecting thelever of serum Total bilirubin(TBIL) in 72 hours after birth. To evaluate therelationship between the serum neuron-specific enolase(NSE)level in 24,72 hoursafter birth and the grade of asphyxia neonatorum;and to study the relationshipbetween the Total bilirubin(TBIL)level in 72 hours after birth and the grade ofasphyxia neonatorum.Methods: 23 asphyxiated mature neonates were selected from neonate ward of TianJin Medical University General Hospital, in which light and severe grade were 14,9respectively(2 in severe grade were died in 24 hours after birth). 10 neonates offull term with no asphyxia selected wereserved as control group synchronously. Allthe neonates in 24,72 hours after their birth were taken blood 2 ml out of the vena fordetermination of the level of NSE by enzyme linked immunosorbentassay(ELISA),and detection the level of TBIL in 72 hours after their birth.ResuIts: In 24,72 hours after birth,there was significant difference in theconcentration of serum NSE between severe grade and control group(P＜0.01); theconcentration of serum TBIL in 72 hours after birth in severe grade group wassignificant degrade comparing to the control group (P＜0.01).Conclusions: It is conducive to early diagnosis of the grade of asphyxial braindamage to detect the concentration of serum NSE; in 72 hours after birth, the severerthe asphyxia is the lower the bilirubine.