Study Of NKA-9 Adsorbing Plasmic Bilirubin In Pathological Jaundice Of Newborn

Objective: To screen a best adsorbent out of four candidate adsorbents NKA-9, NK-110, immunoadsorbent and chitosan as the perfusion adsorbent in the treatment of pathological jaundice of newborn, as well as in vitro investigate its adsorption for the blood bilirubin of pathological jaundice of newborn, investigate its influences on the blood elements and evaluate its biocompatibility.Method: the adsorptive efficiency and adsorptive capacity of four candidate adsorbents NKA-9, NK-110, immunoadsorbent and chitosan for blood bilirubin were tested respectively, and then the best one (NKA-9) was screened out. The NKA-9 was used in the perfusion treatment circulation of the plasma of pathological jaundice of newborn, during the circulation session, parameters at 0min, 10min, 20min, 30min, 40min and 60min were assayed such as TB, DB, TP, ALB, ALT, AST, ALP, GGT, LDH, CK, BUN, UA, K+, nCa, HCO3-, PLT, PT, APTT, FIB, TT, C3, IgG, IgM, IgE, GLU, TC respectively, the biocompatibility of the NKA-9 was also evaluated according the GB/T 16886.Results: NKA-9 has higher adsorptive efficiency for blood bilirubin(82.2%±6.1%). NKA-9 can adsorb blood bilirubin quickly and the adsorptive peak was in 10 min. In perfusion treatment circulation, treating for 60min was a ideal session, and there were significant decrease for TP, ALB, ALT, AST, ALP, GGT, LDH, BUN,UA, FIB, IgE, while there were significant increase for HCO3-, PT, APTT, and TT, but there was no significant change for K+ while nCa has significant change.Conclusion: NKA-9 was biocompatible and the best perfusion adsorbent for the treatment of pathological jaundice of newborn, its adsorptive efficiency for blood bilirubin was significant and highest among the fours, and its effects on most of blood elements were not statistically significant, thus its properties could meet the clinical requirements.