Modified Dihuang Decoction In Prevention And Treatment Of Endometrial Hyperplasia Induced By Tamoxifen

Objective:1. To observe the intervention of modified Dihuang Decoction on breastcancer patients with oral tamoxifen induced endometrial hyperplasia cases.2. Clinical symptoms related to Chinese medicine by tamoxifen therapy in patientswith oral carcinoma of breast of dialectic, and to observe the effects of JiaweiDihuang Decoction on the card is a traditional Chinese medicine intervention inpatients with symptoms of yin deficiency of liver and kidney.3. To evaluate the efficacy and safety of modified Dihuang Decoction Treatment oftamoxifen induced endometrial hyperplasia.4. Assess relevant clinical symptoms of TCM efficacy and safety of modifiedDihuang Decoction to improve oral tamoxifen induced.5. Provide TCM basis and to seek the effective treatment method for the preventionand treatment of breast cancer endocrine therapy due to adverse reactions, developideas for clinical prevention and treatment of diseases related to breast cancerendocrine therapy and provide reference.Methods:1. A random number table grouping method, would be consistent with theannotation of the patients were randomly divided into experimental group andcontrol group,20cases in each group, a total of40cases.2. Clinical age, pathological type, the two groups of patients with breast cancerstaging, course of disease, tamoxifen treatment time, KPS score, endometrialthickness testing, to determine the two groups comparable.3. Method of administration:1) The experimental group: conventional treatment:20mg/, tamoxifen, and with theuse of modified Dihuang Decoction (automatic decocting packing machine decocting,150ml per bag),2times a day, each time1bag.2) Control group: conventional treatment:20mg/, tamoxifen.4. Note: treatment and medication groups were30days for a course of treatment. Atotal of3courses of treatment. During the treatment two groups are strictly inaccordance with each treatment, strictly prohibit the application or combined withother drugs for liver kidney yin deficiency syndrome or measures.5. Reach the course after the review of blood, liver function, renal function, six items,to evaluate drug safety.Results:1. The prevention of endometrial hyperplasia: by statistical analysis, theefficacy of the two groups after treatment were statistically significant (P <0.05), thecurative effect of experimental group was higher than control group. Theexperimental group before and after the administration of endometrial thicknessshowed significant difference (P <0.01), the experimental group after administrationof endometrial thickening degree are improved significantly; while the control groupbefore and after treatment of endometrial thickness had no significant difference (P>0.05). Difference between the two groups after treatment of endometrial thicknesssignificantly (P <0.05), suggesting that in experimental group endometrialthickening were higher than those in control group had significant improvement.2. The improvement of clinical symptom of TCM: by statistical analysis, two groupsof curative effect after treatment were significantly different (P <0.01), the curativeeffect of treatment group was higher than that of control group. Before and aftertreatment in treatment group TCM clinical symptom scores were significantlydifferent (P＜0.01), while the control group before and after treatment of TCMclinical symptom score were no significant difference (P>0.05). After drugtreatment group showed significant difference with the traditional Chinese medicineclinical symptoms (P <0.01), the treatment group of TCM symptoms improvedsignificantly than the control group.3. The quality of life of patients (KPS score) by statistical analysis, the experimentalgroup before and after treatment KPS score was statistically significant (P <0.05),while the control group before and after treatment KPS score showed no statistical significance (P>0.05). After treatment, KPS scores of the two groups wasstatistically significant (P <0.05), suggesting that than patients in the control grouponly received tamoxifen significantly improved quality of life with Jiawei Dihuangtamoxifen in experiment group.4. The safety indicators, such as general (T, P, R, BP), blood routine (HGB, RBC,WBC, PLT), liver function (ALT, AST), renal function (Cr, BUN, UA) and six sexhormones (P, T, E2, PRL, LH, FSH). Before and after treatment, statistical analysis,experimental group, control group had no statistical significance (P>0.05); aftertreatment in two groups had no statistical significance (P>0.05).Conclusions: Modified Dihuang decoction has obvious curative effect on preventionof breast cancer patients with oral tamoxifen induced endometrial thickeningjunction, and can effectively improve the clinical symptoms in patients with Chinesemedicine, to improve the living quality and immunity, the treatment is safe andeffective, no obvious side reaction.