| Purpose:This study aimed to investigate the efficacy of the chinese drug of Jianpihuoxueyiqi for chronic atrophic gastritis clinical symptoms, endoscopy, histopathological effects. And through randomized controlled Weifuchun piece, comprehensive and objective evaluation of the clinical effectiveness of spleen and blood detoxification party. To further develop the treatment of chronic atrophic gastritis hospital foundation preparationMethod:The study collected between December2012to January2014, the Guangdong Provincial Second Hospital outpatient and inpatient cases of chronic atrophic gastritis in60cases. Were randomly divided into two groups:the treatment group of30patients:oral chinese drug of Jianpihuoxueyiqi, daily one; the control group of30patients:Weifuchun oral tablets,3times a day, every three. A course of six months, the main symptoms and syndromes observed before and after treatment candidates, as well as gastric manifestations and pathological manifestations gastroscopy (including6atrophy, intestinal metaplasia, Helicobacter pylori heterosexual hyperplasia, inflammation and activity). By SPSS19.0analysis of data, by examining the relevant indicators of differences. Finally, draw conclusions and correlation analysis, a comprehensive evaluation of the clinical effectiveness of the spleen and blood detoxification party. Results:After six months of treatment, the clinical efficacy of two drugs have chronic atrophic gastritis. Which aspects of the efficacy of the symptoms: the first oral medication after1month follow-up, two to relieve the symptoms of this disease syndrome was no significant difference (P>0.05); medication during the first two months to the end of treatment before symptoms improve contrast case, the treatment group than the control group, there was significant contrast between the two (P<0.05). TCM, the treatment group syndrome cure rate43.33%,26.67%in the control group, treatment group was markedly effective rate of96%, the treatment group was92%(P<0.05). Compare the two groups to alleviate stomach pain, the pain relief effect of the treatment group than the control group, and markedly faster, comparing the two groups was statistically significant (P<0.05). Under terms of contrast endoscopy:gastroscopy revealed according to the thickness of the gastric mucosa, with or without particles hyperplasia, context score, mucosal abnormalities more obvious, the higher the rating, the greater the score decreased after treatment difference, the higher the group to prove efficacy. As a result, comparison of before and after treatment, endoscopy score difference before and after the treatment group compared with the control group, more effective than the control group,(p<0.05). Pathological aspects of gastric mucosa:For two drugs are effective mucosal pathology. Overall, the treatment group was significantly tissue lesions state treatment efficacy was significantly better than the control group (P<0.05); after treatment, comparing the degree of atrophy of the gastric glands, the treatment group was significantly lower than the control group, comparing the two groups was significant (p<0.05). Which, after treatment, the treatment group disappeared shrinking number of up to21people, significantly more than the control group (P<0.05); After comparing treatment, gastric inflammation, the degree of activity, the treatment group was significantly lower than the control group. Conclusion:Comprehensive Evaluation of the results of this study, the Chinese drug of Jianpihuoxuejiedu in the clinical symptoms, gastric mucosal pathology phase changes and improvements have a significant effect, for the clinical treatment of chronic atrophic gastritis effective Chinese herbal formula, no adverse reactions in clinical use, in-depth clinical significance of the study. |
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