Clinical Studies Of Tongfengkang’s Treatment On Gout

Objective:By applying Tongfengkang treatment for patients with gout, observingsigns and symptoms (joint rest pain, joint tenderness, joint swelling, joint function)and laboratory parameters (uric acid, erythrocyte sedimentation rate, high-sensitivityC-reactive protein, urinary albumin/creatinine ratio, cystatin c, urinary-2microglobulin) before and after the treatment, Evaluating the clinical efficacy ofTongfengkang and to explore the role of early renal protective effect.Methods:80patients who meet the inclusion criteria of gouty arthritis were randomlydivided into the control group and treatment group,each group of40cases. Bothgroups were given the same basic treatment. On the basis, treated group were takingTongfengkang decoction twice a day for30days. The control group receivednon-steroidal anti-inflammatory analgesics (indomethacin),three times a day for30days.Making the record for the before and after treatment of joint pain and swellingindex, joint function assessment, syndromes integral value of Traditional ChineseMedicine, the test results of uric acid, erythrocyte sedimentation rate, ultra-sensitivec-reactive protein, urinary albumin/urine creatinine and cystatin and urinary2-microglobulin.Results:(1)After treatment,both the control group and the treatment group patients’joint rest pain, joint tenderness, joint swelling, joint function was decreased thanbefore(P<0.01). compared this two groups, the treatment group has the similar effectwith the control group.(2)fter treatment, UA, ESR and hs-CRP of both the two groups were significantlylower (P<0.01).While the results of the treatment group was more obvious,withstatistical significance (P<0.01). (3)After treatment,the two groups’ symptom scores value of TCM weredecreased(P<0.01).Compared with the control group, There is no significantdifference(P>0.05).(4)Compared the before and after treatment, ACR and Cys c did not changesignificantly in the control group.There is no significant difference(P>0.05). While theACR，Cys c and2-MG is significantly lower in the treatment group (P<0.01),so theeffect of the treatment group was obviously(P<0.01).(5)Making the comparison of clinical efficacy in the two groups. The significantlyefficient rate is47.5%(26/40), effective rate is17.5%(11/40), invalidity rate is7.5%(3/40), and the total efficiency is92.5%(37/40) in the gout treatment group; while inthe control group, they are respectively27.5%（15/40）,45%（18/40）,17.5%（7/40）and82.5%(33/40).There is a significant difference（P<0.01）in the total effective ratebetween the two groups.Conclusion:Treating gouts by Tongfengkang,which has a good clinical efficacy toreduce joint pain, uric acid, erythrocyte sedimentation rate, C-reactive protein, and toimprove joint function. Compared the results of the urinary albumin/urine creatinineand cystatin c and urinary2-microglobulin between the control group and thetreatment group, it’s found that the TongFengKang has an early renal protective effectfor the treated patients.