Clinical Observation Of Alpha Hydroxy Acid Peeling In Treatment Of Moderate Acne

Background: Acne vulgaris is a chronic inflammation of the hair folliclesebaceous glands that occurs in the face. The lesions may manifest as comedones,inflammatory papules, pustules, nodules, cysts and abscesses. The patients generally donot feel any pain unless the inflammation is significant. Its incidence is multiple whichhas been manifested mainly relating to the levels of sex hormones, large amount ofsecretion of sebum, Propionibacterium acnes proliferation, the abnormal keratinizedhair follicle sebaceous glands duct and inflammation, etc. Clinically Tretinoin forexternal use is the first-line drugs for acne treatment and adapalene is the drug of choicefor light to moderate comedones acne and inflammatory acne. Based on specificconditions antimicrobial therapy and combined therapy can be taken. Estrogen orantiandrogen is also used for the treatment of acne. Although there are many therapeuticregimens for treating acne, their side effects, drug resistance and other problems abound.Alpha Hydroxy Acid is a kind of physiological, natural and non-toxic organic acids. It isa small weight molecular which has a strong permeability, weakens cell adhesion ofkeratinocyte, and induces dermal mast cell degranulation and superficial dermaltelangiectasia, so as to achieve the effects of moisturizing, accelerating skin metabolism,reducing melanin and wrinkles, etc. It can reduce the accumulation of keratin andalleviate the hair follicle sebaceous glands duct hyperkeratosis, while domestic studieshave shown that it can inhibite Propionibacterium acnes, which enables it to treat acne.Objective: To observe the efficacy and safeness of Alpha Hydroxy Acidpeeling in the treatment of moderate acne, and to evaluate the skin non-invasivedetection techniques in assessing skin physiological changes.Methods: Alpha Hydroxy Acid concentration of20%,35%,50%or70%of wasapplied to treat20cases of patients with moderate acne four times for treatment withintervals of three or four weeks. Before each treatment and two weeks after the lastsame one person counts the number of inflammatory lesions and noninflammatory lesions and record by camera, meanwhile test the changes of TEWL, stratum corneumwater content, skin elasticity, skin color by the skin physiology tester. This study usedown control for observation and evaluation.Results:20cases of moderate acne patients were enrolled. The total effective ratewas100%, which includes cure rate, obvious effective rate and response rate that were55%,35%and10%, respectively. The inflammatory skin lesions subsided better thannon-inflammatory skin lesions; the patients’ skin texture was significantly improved andthe difference was statistically significant (P <0.05).Conclusions:1. Alpha Hydroxy Acid peeling was safety and effective in moderateacne treatment. It had little side effect, which can be avoided, and improved skin texturesignificantly.2. Skin physiology tester can be applied to observe the changes of TEWL, stratumcorneum water content, skin elasticity and skin color before and after the acne treatment,so as to quantify the effect of Alpha Hydroxy Acid peeling in moderate acne treatmentmore scientifically and objectively.