Investigate The Physiological Indicators Of Facial Skin In Patients With Mild To Moderate Acne And Healthy Individuals

Background Acne vulgaris is a chronic inflammatory disease in hair follicles and sebaceous glands,its pathogenesis is related to many factors.In recent years,the "skin barrier" may have a certain correlation with the formation of skin disease,which became an important focus of scholars.With the updated application of non-invasive skin physiometry instruments,the skin cutin layer water content,transepidermal water loss(TEWL),skin sebum,skin PH,skin melanin,skin hemoglobin,skin elasticity and so on can be detected effectively,testers can understand the skin conditions directly and objectively.More and more skin physiometry researches indicate that the function of skin barrier in acne patients becomes abnormally.In addition,in the process of clinical treatment,the skin physiological indexes can also have changes.they will tend to be normal and stable with the healing of acne lesions.Many skin physiological statistics have obvious differences compared with normal skin,but some indexes have not been found the difference compared with healthy volunteers.As a result,more and more scholars think that the damage of skin barrier may be associated with the occurrence and development of acne,effectively protect and repair the skin barrier can play an important role on the control and treatment of acne.Objective Through measuring the skin physiological indicators of patients with mild to moderate acne and healthy individuals,we can analyze their difference and investigate the association of abnormal skin physiological indicators with occurrence and development of acne.Therefore,we can provide theoretical basis for the acne prevention,control and treatment in the future.Methods Select 114 volunteers in this study,including 57 patients with mild to moderate acne(24 males and 33 females)and 57 healthy human controls(24 males and 33 females).The average age of patients and controls was both 22 years.We use non-invasive physiometry instruments detect the skin cutin layer water content,transepidermal water loss(TEWL),skin sebum,skin PH,skin melanin,skin hemoglobin and skin elasticity in the following areas: forehead,nose and cheek.In addition,we only detect the skin elasticity in the canthus.Then we analyze all the indicators of each part to know the difference between acne patients and controls.Results The skin cutin layer water content of forehead and cheek in patients is lower than controls(P < 0.05).The transepidermal water loss(TEWL)of forehead and cheek in patients are higher than controls(P < 0.05).A significant increase is also observed inthe level of skin sebum secretion and hemoglobin in the forehead,cheek and nose of patients compared with controls(P < 0.05).However,the level of skin PH,skin melanin,skin elasticity of forehead,cheek and nose,the level of skin cutin layer water content and transepidermal water loss(TEWL)of nose,the level of skin elasticity of canthus are all of no significant difference between the patients and controls(P > 0.05).Conclusion Compared with the controls,facial sebum secretion of patients with acnincreases obviously.With regard to forehead and cheek occured with acne easily,thskin cutin layer water content is lower than controls,the transepidermal water los(TEWL)and skin hemoglobin are higher than controls,the skin barrier is damagedHowever,we have not find the difference of the skin PH,melanin,and elasticitbetween patients and controls.