The Analysis Of Hypothyroid Factors After¹³¹I Therapy For Graves’ Disease

Objective：Hypothyroidism is the most complications of hyperthyroidism¹³¹Itherapy，but the mechanism is unclear and it is lack of the interventions. So it isthe main topics of¹³¹I therapy for hyperthyroidism clinical research. This paperdiscusses the influencing factors of hypothyroidism after¹³¹I therapy of Graves’hyperthyroidism.Methods：It was retrospective review of the patients with¹³¹I for GD fromJanuary2011to July2011at the department of nuclear medicine，the First AffiliatedHospital of Nanchang University. The190patients with Graves’ diseaseunderwent¹³¹I who were followed up for1year patients. According to the treatmenteffect, they were divided into3groups hyperthyroidism group, hypothyroidism group,cured group. Then we analyze the relationship between gender, age, thyroidweight, duration of treatment, whether accept antithyroid drug （ATD） beforethe¹³¹I treatment, the dose of the¹³¹I, the conversion rate of the¹³¹I,thyroidperoxidase antibody （Anti-TPO） and so on. The data were analyzed by SPSS17.0.We used the multiple logistic regression analysis to analyze the multifactorinteraction. Also we used one-factor ANOVA to analyze the single factor which caninfluence the final result among the different groups.Results： After one year,52%of the patients were cured,25%of the patientswere hyperthyroidism all the same and23%of them were hypothyroidism. Theresults of multiple logistic regression analysis shows that the dose of the¹³¹I, theconversion rate of the¹³¹I, Anti-TPO and the thyroid weight are the factors which caninfluence the occurrence of the hypothyroidism. The results of the one-factor ANOVAshow that the difference of the dose, the conversion rate of the¹³¹I,Anti-TPO andthyroid weight were statistical significantly among the different groups.Conclusion：1.¹³¹I is an important treatment for Graves disease. The therapy of¹³¹I is related to the dose of the¹³¹I, the conversion rate of the¹³¹I,Anti-TPO and thethyroid weight and is not related to age, gender, duration of treatment, whether accept antithyroid drug（ATD） before the¹³¹I treatment.2.The the incidence of hypothyroidism is positively correlated with the dose ofthe¹³¹I, the conversion rate of the¹³¹I and Anti-TPO，while it is negatively correlatedwith thyroid weight.3. In this study, the univariate analysis and multivariate analysis were used. Theunivariate analysis and multivariate analysis gap is mainly due to the interactionbetween the influencing factors after¹³¹I therapy for Graves’ disease. Multivariateanalysis can solve the problem that the univariate analysis can only study one factorevery time.