1.the Research Of Clinical Therapeutic Effect In ¹³¹I Treatment Of Graves' Disease And Affecting Factors 2.the Research Of The Correlation Of Serum Anti-C1q Autoantibodies (C1qAb) With Graves' Disease

ObjectiveTo evaluate the clinical therapeutic effect in ¹³¹I treatment of Graves'disease(GD), explore its affecting factors.Methods1.182 GD inpatients in our hospital after ¹³¹I treatment had been followed up.To test the serum thyroid function after one year,these subjects had been divided into four groups: hyperthyroid group,euthyroid group,hypothyroid group,recurrence group,according to the present medications such as ATD,L-T4 .To account the respective probability and successful cure probability.2.The euthyroid group and the hypothyroid group had been merged into the successful cure group,while the hyperthyroid group and the recurrence group into the unsuccessful group.The clinical data had been compared prior to treatment between these two groups:age,thyroid size,2-h and 24-h thyroid ¹³¹I uptake values,serum FT3 and FT4,given ¹³¹I (mCi/g)called ¹³¹I treatment coefficient,total ¹³¹I dose (mCi),dose ¹³¹I to thyroid /g tissue (mCi/g).The correlation was analysed between the four factors : thyroid size,dose ¹³¹I to thyroid /g tissue,FT4,¹³¹I treatment coefficient and successful cure in Logistic Regression.Results1. 114 patients had been successfully followed up,32 patients(28%)had persistent hyperthyroidism, 41(36%),37(32.5%),4(3.5%)were euthyroid,hypothyroid,recurrent hyperthyroidism respectively. The percentage of successful cure(euthyroidism or hypothyroidism)is 68.4%,unsuccessful cure(persistent or recurrent hyperthyroidism)31.6%.2. The thyroid size and level of serum FT4 before treatment in the successful cure group were lower than the unsuccessful group(persistent or recurrent hyperthyroidism),p=0.004,0.042 respectively; coefficient and dose ¹³¹I to thyroid /g tissue are obviously higher,p=0.002,0.000 respectively.3. In these four factors'correlation with successful cure analysed by Logistic Regression,dose ¹³¹I to thyroid /g tissue had a significant impact in successful cure(p=0.049).4. The 2-h thyroid ¹³¹I uptake(%)of GD suffers had a linear regression with thyroid size(ECT,g). But 24-h thyroid ¹³¹I uptake hadn't.Conclusions1.Successful cure rate is 68.4% in our used ¹³¹I dose.Euthyroid 36%;hypothyroid 32.5%.2.Thyroid size,serum FT4,¹³¹I treatment coefficient,dose ¹³¹I to thyroid /g tissue may become the indicators of prognosis;dose ¹³¹I to thyroid /g tissue is independently and positively with successful cure;it is in favor of successful cure if the ¹³¹I treatment coefficient is 0.096～0.107mCi/g. Part twoThe research of the correlation of serum anti-C1q autoantibodies(C1qAb)with Graves'diseaseObjectiveTo detect the serum anti-C1q autoantibodies(C1qAb)concentration in patients with Graves'diseas(eGD), analyse the correlation of serum level of C1qAb with thyroid function and its clinical significance.MethodsThirty-one patients first diagnosed as GD(Female 21,Male 10)were enrolled in this study;thirty-three euthyroid healthy volunteers whose age,gender,body mass index(BMI) matched with GD group were chosen as control group.The serum thyroid function and level of C1qAb were measured by chemiluminescence and enzyme-linked immunosorbent assay respectively.ResultsThe serum level of C1qAb in GD patients was significantly higher than that of healthy control group[(461±226 vs 103±56)IU/ml,p=0.000],it was positively associated with FT3(r=0.584,p=0.001)and FT4(r=0.551,p=0.001).ConclusionSerum level of C1qAb is associated with thyroid function. The measurement of serum C1qAb concentration appears to be helpful to monitor the hyperthyroidism condition. It may have certain roles in the pathogenic mechanism of GD.