Clinical Retrospective Analysis Of Iodine-131 Therapy For Graves' Disease

Objectives:To analyze the treatment effects for Graves' disease and the related factors,and evaluate the outcome of hypothyroidism and other side effects, and probe into ¹³¹I treatment for juvenile Graves' disease and complications of thyroid diseases.Materials and Methods:of the 942 cases with Graves' disease who accepted ¹³¹I therapy,770 cases were successfully followed up.203 males,567 females,average age 40.39±11.29(19-77)years,average course 3.64±4.05 (1week-24years)years.55 patients with hyperthyroid heart disease,51 patients with ophthalmopathy,141 patients with hyperthyroid liver damage,14 cases with periodic paralysis.699 cases treated with the anti-thyroid drugs.The factors of patients such as patients' syndrome and course of disease were taken into consideration when deciding the doses of ¹³¹I.Statistical analyses were performed with SPSS version 11.5.Results:1.To analyze the treatment effects for Graves' disease and the related factors:Among 770 patients,358 patients(45.19%)were cured.260 patients(33.77%)were improved.21 patients(2.73%)were ineffective.141 patients(18.31%)were developed hypothyroidism.Total effect rate was 97.27%. There are significant differences in the groups with different weight of thyroid gland before treatment and different ¹³¹I absorption dose per gram thyroid gland tissue(p＜0.05),but there is no significant differences in other groups(P＞0.05).2. The outcome of hypothyroidism after ¹³¹I treatment:the most of early hypothyroidism appeared in 2-6 months after ¹³¹I treatment.227 cases(29.48%) appeared at 3 months,154 cases(20.00%)appeared at 6 months,130 cases (16.88%)at 12 months.3.¹³¹I treatment for juvenile Graves' disease:Among 53 patients,25 patients(47.17%)were cured.20 patients(37.74%)were improved.3 patients(5.66%)were ineffective.Total effect rate was 94.34%.X² test revealed that the differences of the curative effects between juvenile and adult were not significant(P＞0.05);4.¹³¹I treatment for complications of Graves' disease is also effective(see table 13).Conclusions:¹³¹I treatment of Graves' hyperthyroidism is effective,less expensive and relative safe.¹³¹I treatment for juvenile Graves' disease is also effective,safe and simple,the age limit has been relaxed gradually.¹³¹I treatment for complications of Graves' disease is also effective.