Xuanfei-Zhisou Decoction For Treatment Of Cough After Infection And The Experimental Study Of Airway Inflammation

This topic makes a complete and comprehensive summary of cough after infection disease’s (post infectious cough, PIC) name, etiology, pathogenesis and treatment methods, than clears that the post infection cough is a common clinical disease importance。The Chinese medicine is not yet about this disease and the exact name of disease record system, in recent years, as people’s understanding of PIC gradually deepened, etiology and pathogenesis, syndrome of this disease treating medicine is more and more, but on the whole, still lack of systematic discussion. According to the characteristics of this disease syndrome, Professor Zhu Jia thinks that PIC is different from other cough disease, has its own unique characteristics, that PIC is "wind cough medicine" category, the basic pathogenesis is the six exogenous pathogenic factors for the disease, loss of treatment, leading to deficiency of vital qi, evil nostalgia, cough, persistent unhealed, prone to injury of Tianjin dryness, Metamict his disease. Through the clinical research on120cases of PIC were treated with Xuanfei-Zhisou decoction treatment, patients were observed before and after treatment (14days for a course) clinical symptoms, cough visual analogue score and positive change of NO measurement, to evaluate the curative effect analysis. The results show, Xuanfei-Zhisou decoction has obvious therapeutic effect on PIC, the total effective rate was94.29%, the control group the total efficiency was80%, there was significant difference between the overall efficacy of the two groups before and after treatment (P<0.01); and NO value were measured and compared after expiration of cough after infection patients have different degree increased expiratory NO, and Xuanfei-Zhisou decoction can significantly reduce the expiratory NO value, there is significant difference compared with the control group (P<0.01), which also shows that the cough after infection exist in the patients with airway hyperresponsiveness in a certain extent.The experimental research, establishment of rat model of cough by the tutor leading talent project created after infection (has repeatedly test beforehand and confirmed the successful model), based on the successful replication model, were observed and airway inflammation is closely related to the inflammatory cytokine, curative effect of cough in Xuanfei-Zhisou decoction in the treatment of infection on dispersing lung after the deep study and discussion. Experiments to test the rat bronchoalveolar lavage fluid in total, the percentage of cells in various types of cells, the pathological changes in lung tissue and the content of IL-4, IL-5, IL-8, TNF-α changes. The experimental results show that:(1) Xuanfei-Zhisou decoction can reduce neutrophils, lymphocytes and other inflammatory cell recruitment to the airway, which may be related to the inhibition of airway allergic inflammation neutrophil differentiation and proliferation, reduce neutrophil chemotaxis to the inflammatory area, aggregation and infiltration, thus reducing the formation of inflammatory mediators on lung tissue and airway epithelial damage and airway hyperresponsiveness, thus has the airway inflammation;(2) Xuanfei-Zhisou decoction by inhibiting the release of cytokines, inflammatory cells, alleviate the airway inflammation, airway hyperresponsiveness should be reduced, thus effectively in treating cough after infection.