| Objective: This study observed modified DangGuiShaoYao Powder and WuPiYingtreatment the type of blood stasis and water mix together of chronicglomerulonephritis.To explor its clinical efficacy, safety, and explore its therapeuticmechanism.Methods: Case inclusion criteria to select a of chronic glomerulonephritis the (bloodstasis and water mix together) patients,60patients randomized design analysiscontrolled observation, the treatment group and the control group observed cases theratio of1:1, the treatment group,30cases The control group of30patients. Controlgroup using conventional western medicine treatment to the lipid-lowering ACEI orARB, diuretics, glucocorticoids; treatment group used in combination the WM grouptherapy based on traditional Chinese medicine Angelica and Peony Powder Five skindecoction treatment. Treatment for90days. Urinalysis observe the treatment andcontrol groups before and after treatment, liver function, kidney function, bloodbiochemistry, urine analysis in red blood cell (RBC) count,24-hour urinary proteinexcretion observation of clinical examination and symptoms change, and every15days to make comprehensive review urine analysis and24-hour protein excretionefficacy evaluation.Results:1, two groups of the total efficiency compared, the difference was statisticallysignificant (P <0.05). 2, the the TCM major symptoms efficacy comparison, the difference wasstatistically significant (P <0.05or P <0.01), the control group improved symptomsless than the treatment group.3, the treatment group and the control group after treatment can significantlyimprove the clinical symptoms and lower symptom score, treatment group markedlyimprove the clinical symptom score than the control group (P <0.05).4,24h urinary protein quantitative indicators:24h urine protein has decreased inthe treatment group and the control group after treatment, and the decline in thedegree of contrast have statistically significant (P <0.05), and the effect of treatmentgroup than the control group.5, the treatment group and the control group after treatment can improve thechanges in red blood cell count in the urine, the control group decreased urine redblood cell count indicators to improve the situation significantly less than thetreatment group (P <0.01).6, Renal function (Scr, BUN) indicators improved: the end of treatment, thetreatment group’s renal function status there is a certain improvement in renal functionstatus of the control group decreased slightly, and the difference between the twogroups are compared with the group before treatment was not statistically significant(P>0.05).7.Improvement in eGFR indicators: urine eGFR before and after treatment thedifference was not statistically significant (P>0.05, P>0.01) after treatment in bothgroups eGFR no significant improvement. After treatment, eGFR difference was notstatistically significant (P>0.01), the treatment group improved eGFR improvedeGFR not comparable with the control group.Conclusion: According to the blood circulation, diuresis swelling the case of theBlood stasis and water mix together chronic of glomerulonephritis dialectical,theDangGuiShaoYao Powder and WuPiYing, can significantly improve the clinicalsymptoms and side effects. |
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