Study On Clinical Related Factors And TGP’s Treatment Of Palmoplantar Pustulosis

Objective:To investigate the related pathogenic factors of Palmoplantar Pustulosis by analyzing the clinical features and the results of patch test, at the same time, observe the therapeutic effect of total glucosides of paeony(TGP) in treatment of Palmoplantar Pustulosis. Finally, provide reasonable methods for prevention and treatment.Methods:1.197cases of Palmoplantar Pustulosis patients were selected and all of them were treated in Changzheng Hospital of Tianjin from March2011to February2013.All patients were interviewed by questionnaire survey to acquire detailed medical history.2. Some of them were tested by patch test(PT) for the information required.3.Ninety patients were randomized into the treatment group and the control group.The treatment group was treated with TGP,the control groups were treated with glucosidorum tripterygii tororum.At the same time all use Mometasone Furoate Cream. And then compare treatment datas and adverse reactions after8weeks.Use statistics software of SPSS18.0to sort out the data.Results:1.In197cases of Palmoplantar Pustulosis, male to female ratio was1:1.32. The Peak ages of the first onset distributed from41to51years, the course of disease was within five years, Most of the patients were workers and farmers. There is no obvious difference at season of onset. The prominent factor for trigger or aggravation of Palmoplantar Pustulosis was inheritance.87patients were smokers.3patients had a history of psoriasis vulgaris.Most of the rash appeared the palm to the the thenar best hair, foot arch best hair.2. It was found that113cases of Palmoplantar Pustulosis were patch tested,84cases showed positive reaction to one or more allergens, the total Positive rate was74.34%, the allergens with high frequency of patch test were potassium dichromate(32.74%), nickel sulfate(29.2%).3. The response rate of the treatment group was40%and64.44%for control group after4weeks.There was significant difference between the treatment group and the control group(P<0.05).The response rate of the treatment group was80%and88.89%for control group after8weeks.There was no significant difference between the treatment group and the control group(P>0.05). we find5cases in the treatment group which had adverse reactions,and8cases in the control group. There was no significant difference between the treatment group and the control group(P>0.05).Conclusions:1. Palmoplantar Pustulosis is more common in female.2. The prominent factor for trigger or aggravation of palmoplantar pustulosis may be inheritance.3. Smoking plays an role in the prevalence of palmoplantar pustulosis.4. Potassium dichromate, nickel sulfat may be the potential factor for trigger or aggravation of palmoplantar pustulosis.5. Palmoplantar Pustulosis can be considered as a separate condition from psoriasis.6. TGP have significant effects on palmoplantar pustulosis with fewer side effects and good safety.