The Investigation Of Helicobacter Pylori Among Recruits And Its Correlational Studies With Functional Dyspepsia

Objective To investigate the infection rate of Helicobacter pylori (Hp) among recr--uits and the affecting factors, the functional dispepsia (FD) rate among recruits, the relationship between the FD and Hp infection,the correlation between Hp infe--ction and serum pepsinogen in FD patients.Methods1.500recruits were chosen randomly as investigation subjects. Basic information including age, nation, degree of education,living condition before enrolling, smok-ing,drinking and post history of taking medication,FD symptom score and epidemic Hp infectional factors were surveyed by questionnaire. Hp infection rates was dete-cted with13C-urea breath test, serum Hp-IgG antibody test and Hp Stool antigen test. At least two methods results positive at the same time were considered as pres--ence of Hp infection.Hp infection-related factors were statistically analyzed;2. All the cases whose FD symptom self-assessment scale score were equal or more than6points underwent gastroscope, no obvious abnormal (the exclusion of organic disease such as peptic ulcer, reflux esophagitis, gastric cancer) under gastroscope and conform to the FD Roman Ⅲ diagnostic criteria for diagnosis of FD patients; Rando-mly selected part of the FD symptom self-assessment scale less than6points under--went gastroscopy, no obvious abnormal recruits watched under gastroscope as normal control group, combined with the first part of the test results of Hp infection status, analyzed the correlation between Hp infection and FD; 3. Pepsinogen (PG Ⅰ,PG Ⅱ, PG Ⅰ/PG Ⅱ) levels were detected in FD patients be confirmed, and analyzed correlation between pepsinogen levels and Hp infection in FD patients;4.Stratified sampling:all statistical data are processed with SPSS17.0software, Hp infection rate presented in percentage, rate compared with χ2-test. PG levels Pres--ented in x±s, compares the two independent sample with t-test, P<0.05for the difference was statistically significant.Results1. Hp positive cases were173, positive rate34.6%(173/500) in500cases, living environment before recruitment were the influence factors of Hp infection, and the degree of education, history of smoking, drinking and taking NSAIDS drugs had no significant correlation with Hp infection;2. In500cases, there were162cases whose FD symptom self-assessment scale score were equal or more than6points,8cases were excluded with peptic ulcer,17cases with reflux esophagitis. There were137cases watched under gastroscopes were no obvious abnormal,126cases were found with functional dyspepsia Rome III diagno-stic criteria and FD incidence of25.2%(126/500). There were338cases whose FD symptom self-assessment scale score were less than6points, randomly selected70cases do gastroscopy,2cases were excluded with peptic ulcer,4cases with reflux esophagitis. There were64cases whose gastroscopes were no obvious abnormal as control group. In the FD group, Hp infection rate was49.21%(62/126),that was significantly higher than the normal control group28.12%(18/64), the difference was statistically significant (χ2=7.738, P<0.05).3. In patients with FD, The levels of PG Ⅰ, PG Ⅱ,PG Ⅲ/PG Ⅱ were respecti--vely137.93±27.73ug/L,7.05±3.92ug/L,24.69±15.5in Hp-positive group, and in Hp-negative group,their levels were respectively131.17±26.38ug/L,2.85±2.11ug/L,64.0±76.44, compared the two groups difference was statistically significant (tⅠ=2.714, tⅡ=17.432,tⅠ/Ⅱ=5.270, P<0.05).ConclusionsThe infection rates of Hp were34.6%in the new recruits, living environments before recruitment were the influence factors of Hp infection; The morbidity of FD was25.2%and it may have a certain correlation with Hp infection; In patients with functional dyspepsia, Hp infection may cause elevated pepsinogen PG I, PGⅡ levels, priority to PG II.