The Clinical Significance Of Changes Of Pepsinogen Level In The Peripheral Blood Of Chronic Gastropathy Patients With Helicobacter Pylori Infection

Objective:Though the detection of PG (Pepsinogen, PG) level andthe level of variation in the different chronic gastropathy patients withHP(Helicobacterpylori,HP)infection and non-HP infection,Investigate thevariation of PG (Pepsinogen, PG) level in the chronic gastropathy patientswith HP (Helicobacter pylori, HP) infection associated with from changesin the development of the process chronic non-atrophic gastritis-chronicatrophic gastritis-intestinal metaplasia-dysplasia-intestinal type gastriccancer.To provide experimental evidence for diagnosis and treatment ofthe early gastric.Methods:Use double antibody sandwich enzyme-linked immune-osorbent assay to parallel detecte the the PG level in peripheral blood of40patients with chronic superficial gastritis patients (HP infection in29cases,11cases of non-HP infection);27cases of patients with atrophicgastritis (HP infection18cases of non-HP infection9cases);28cases ofpatients with gastric polyps;22patients with gastric cancer whichscreened by14C urea breath test (14C-UBT),observe the changes of PGlevel in patients with different groups;and also detecte the the PG level inperipheral blood of chronic superficial gastritis, atrophic gastritis patients related with HP infection and non-HP infection, to observe HP infectionon impact of the changes of PG level.Results: The PGI content has decreased in the healthy controlgr-oup, superficial gastritis, gastric polyps, atrophic gastritis (CAG) andgastric cancer patients,except healthy control group，between each grouphad statistical significance (P＜0.05). from gastric polyps, superficialgastritis, CAG to gastric cancer group PG II concentration graduallyincreased, but between each group had statistical significance (P＜0.05).the PGI/PG Ⅱof each groups from superficial gastritis, gastric polyps,CAG to gastric cancer group gradually decreased,compared to superficialgastritis,between each group had statistical significance (P＜0.05); thesignificant difference in patients with atrophic gastritis withHP infectionand non-HP infection in the peripheral blood of PGI level,PGⅡ levelssignificantly higher, PGI/PG Ⅱ ratio was significantly lower (P <0.05,P <0.05).Conclusions:Chronic HP infection cause gastric mucosal atrophy inturn affect the the PG protein expression and is closely related to gastriccancer development, when gastric mucosal atrophy or cancerous,gastricsecretory capacity decreased, with PG Ⅰin peripheral blood of patientsdecreased. Lower PG Ⅰ and PG I/PG Ⅱ should be alert to early gastric cancer, and has important implications for the early diagnosis ofgastric cancer.