| Objective: In large and medium-sized cities of China, lung cancer is theone of the highest morbidity and mortality of cancer. Advanced lung cancerpatients often lose the opportunity of surgical treatment, however due to manyside effects the chemotherapy and radiotherapy greatly affect the patient’squality of life, and even lead to psychological disorders. At present given thathas not yet found a systematic and in-depth study on quality of life of themiddle-late patient with lung cancer in our reginon, so in Hebei ProvincialTumor Hospital to conduct a survey to the middle-late patients with lungcancer to evaluate the status of the quality of life and to find out the relevantfactors affecting the quality of life, in order to facilitate to take comprehensiveinterventions to improve the quality of life of patients with lung cancer.Methods:154inpatients with advanced lung cancer Selected in therespiratory medical and oncological department of fourth hospital of HebeiMedical University (Hebei Provincial Tumor Hospital) using a self-designedquestionnaire for the quality of life of patients with lung cancer,66entries and8dimensions included such as general situation, lung cancer-relatedsymptoms, overall evaluation of the quality of life, cognitive function,emotional function, physical function, role function and social function bydirect follow up or telephone surveys to patients. Using frequency to describethe demographic characteristics of patients with lung cancer, and using theQLQ-C30scoring method to describe the five functional dimension tableincluding cognitive function, emotional function, physical function, rolefunction, and social function. According to data normality and homogeneity ofvariance, selecting10variables such as gender, age, educational level,economic status, marriage and smoking take t test or rank-sum test fordichotomous variables, take single factor variance analysis or rank sum test to multi-categorical variables, using LSD test carry out comparison between thegroups or Bonfferoni adjustment method carry out two comparison betweenthe mean numbers. Using four or five levels to describe the findings of theoverall evaluation of the quality of life, lung cancer-related symptoms, andeach entry in the survey results in the five functional dimension, in order toshow that Coefficient of Rank Correlation eg statistical analysis Index of Rankcorrelation degree to describe the association degree. Correlation analysisusing Spearman rank correlation analysis correlation degree of each item withthe overall quality of life. Standard test to P<0.05is of significant difference,P>0.05is of no statistical significan.Results:1The impact of the demographic characteristics on the patient ’s qualityof life.Age, economic status, smoking status and etc have showed a significantimpact on quality of life (P<0.05), and also shown significant differences (P<0.05) in each age groups on the role function and social function entry. Thereare very significant differences between the role function and social functionentry in middle-aged and elderly groups (P=0.008); also very significantdifferences between the social function (P=0.009). Youth group and themiddle-aged group no difference. There are very significant differencesbetween the economic conditions in the medium and low (P=0.004). Passivesmokers have shown differences on cognitive, emotional role function withnot smoking patients (P<0.05).2Impact of clinical symptoms on quality of life in patients with lungcancer.Common symptoms in patients with lung cancer, such as shortness ofbreath, pain in the arm or shoulder, nausea, vomiting, and fever etc wasnegatively correlated with quality of life (P<0.05or P<0.01), the loss ofappetite, cough, pain and fatigue was no correlated with quality of life(P>0.05).3Correlation of the quality of life of patients with lung cancer with the functional dimension.The satisfaction of the current quality of life of patient with lung cancer isrelative with their cognitive function, emotional function, physical function,role function and social function in multiple entries. Anxiety, anger, despair,confusion, loneliness, fear and other emotions, as well as shortness of breath,arm or shoulder pain, nausea, vomiting, fever, loss of weight, and other partsof the pain and other symptoms have shown negatively correlated with qualityof life. The other entries were positively correlated with the quality of life.Correlation (P<0.05or P<0.01) and the absolute value of correlationcoefficient>0.3items include: fever, enjoy life, never ignore disease, focused,to participate in various recreational activities, actively to do want to do thingsgood relationship, with friends, acquaintances, etc.Conclusions:1The quality of life of patients with advanced lung cancer is associatedwith a variety of factors. Age, economic status, and smoking status have asignificant impact on quality of life, should pay special attention on the youngand poor economic patients with lung cancer.2Closely related to cognitive function with quality of life. Lung cancerpatients are encouraged to correctly understand and treat the disease,optimistic in the face of reality, and confident about the treatment, enjoy life,strive to maintain a normal life and not be plagued by problems, and improvethe quality of life of patients with advanced lung cancer.3Anxiety, anger, despair, confusion, loneliness, fear and other emotionsare negatively correlated with the quality of life, and gratifying sense ofemotional self-control, try to make yourself happy, recreational activities and asense of hope was positively correlated with quality of life of patients withadvanced lung cancer.4Social roles and physical function are closely related with quality of life.Good relations with friends and acquaintances, paying attention to the physicalexercise, doing housework, husband-wife good relationship and helpfulnesswere positively correlated with the quality of life of patients with advanced lung cancer, and showed relatively close relationship.5Fever, shortness of breath, nausea, vomiting, arm or shoulder pain andother symptoms seriously impact on the quality of life of patients withadvanced lung cancer and should be treated aggressively. |
