Risk Factors Of Mood Disorders And Correlations Between Mood Disorders And Quality Of Life In Lung Cancer Patients

Objective: Lung cancer patients are easily under sense of helplessness and hopelessness, which may lead to mood disorders and reduces significantly their quality of life. The study is completed by patients-coming from the department of oncology, Fourth Hospital of Hebe Medical University, Second Hospital of Hebe Medical University, Affiliated Hospital of Hebe Universitycompleting questionnaire of SAS, SDA and QLQ-C30. And the purpose of study is to explore the risk factors of mood disorders anxiety/depression and identify the correlations between mood disorders and quality of life in lung cancer patients, thus providing clues for improving omni-directional service of lung cancer patients.Method:1 The data was obtained from the department of oncology, Fourth Hospital of Hebe Medical University, Second Hospital of Hebe Medical University, Affiliated Hospital of Hebe University. Between February 2015 and December 2015, a total of 283 patients who were diagnosed of lung cancer were enrolled in the study. All patients were asked to write informed consent.2 The related factors of anxiety and depression in lung cancer patients were collected. The other data were obtained from the self-administered questionnaires: SDS, SAS and QLQ-C30.3 Statistical analysis: SPSS21.0 software was used for all the data analyses. The lung cancer patients were divided into with or without anxiety groups / with or without depression groups, associated factors were compared by ?2 tests and their risk factors was identified by binary logistic regression in a multivariate analysis. According to whether the data was satisfied with normality and homogeneity of variance, one-factor ANOVA test or Wilcoxon rank sum test was used to compare the differences in different areas of the quality of life between anxiety group and without anxiety group/depression group and without depression group. Spearman's rank correlation was used to analyze the correlations between anxiety/depression and QLQ-C30 areas. In all the statistical evaluations, P values of <0.05 were considered to be statistically significant; all the P values were two-tailed.Results: 1 A total of 283 lung cancer patients were enrolled in the study. The prevalence rate of anxiety was 23.0%(n=65), with mild anxiety 16.6%(n=47), moderate anxiety 5.3%(n=15), severe anxiety 1.1%(n=3).The prevalence rate of depression was 33.9%(n=95), with mild depression 22.3%(n=62), moderate depression 8.5%(n=24), severe depression 3.2%(n=9). The cases of patients both with anxiety and depression were 47(16.3%).2 Variables significantly related to anxiety were gender, metastasis, place of residence, performance status, therapy and the treatment stage(P<0.05), and age, BMI, income, education, marital status, employment, informed of the disease, cancer types, TNM and disease duration showed no correlations with anxiety in lung cancer patients(P>0.05).Variables significantly related to depression in lung cancer patients were marital status, metastasis, place of residence, performance status, disease duration, therapy, and the treatment stage(P < 0.05). Between with depression group and without depression group, no statistical differences were found regarding to age, gender, BMI, income, employment, education, informed of the disease, cancer types and TNM(P > 0.05). The performance status was the risk factor associated with depression in logistic regression multivariate analysis. Performance status, gender and the treatment stage were the risk factors associated with anxiety. 3 The study showed statistically significant differences on QLQ-C30 areas between the anxiety group and without anxiety group(except diarrhea, P=0.165)/the depression group and without depression group(P<0.05). There were significantly inverse correlations between the mood disorder anxiety and depression and the physical function, role function, emotional function, cognitive function, social function and the global health and quality of life, and positive correlation between mood disorder and the symptoms(fatigue, pain and nausea/vomiting) and single symptom items(dyspnoea, insomnia, appetite loss, constipation, diarrhoea, and financial difficulties). Comparing with without anxiety/depression group, the life quality in lung cancer patients with anxiety and/or depression was decreased.Conclusion:1 Anxiety and depression are common in lung cancer patients, and the prevalence rates of mild anxiety and depression are high, and the results are consistent with reports at home and abroad.2 Metastasis, place of residence, performance status, therapy, and the treatment stage correlated significantly with anxiety and depression in lung cancer patients. Besides, gender correlated with anxiety; marital status and disease duration correlated with depression.3 The performance status was the risk factor associated with depression in logistic regression multivariate analysis. Performance status, gender and the treatment stage were the risk factors associated with anxiety.4 The mood disorder anxiety and/or depression are clearly related to the reduced quality of life in lung patients.