Saccharomyces Boulardii In Prevention Of Infant Antibiotic-Associated Diarrhea Clinical Investigation

Background and ObjectivesAntibiotic-associated diarrhea refers to the use of antibiotics after,associated with antibiotics,and there is no other reason can explain the diarrhea.Also include diarrhea,As a result of the adverse reactions of antibiotics itself.It occurs in antibiotic treatment after48h,24h in above3times liquid or deformed.Bartlett defines it as:with the use of antibiotics and other reasons can’t use diarrhea.In recent years,broad spectrum antibiotics in pediatric application more and more.The resulting antibiotic associated diarrhea are also rising year by year.Children treated with broad-spectrum antibiotics,the incidence of AAD was11%～40%.More than80%occurred in the application of4-5antibiotics day Any antibiotics can cause AAD.Typical incidence is5%-35%.It is the most common type of iatrogenic diarrhea.Application of antimicrobial agents for the hospitalized children with one of the most common drugs.Although have saved the lives of countless people,but also produced a series of problem that nots allow to ignore.The common side effects AAD has begun to receive more attention.The occurrence of AAD mechanism:①intestinal flora imbalance②antibiotics interfere with sugar and bile acid metabolism;③of antibiotics allergy,the direct toxic effect on the intestinal mucosa;④pharmacological effect on intestinal dynamic change. The clinical study abroad confirmed Saccharomyces boulardii (SB) can effectively prevent the occurrence of AAD in children, but the domestic study on SB prevention of childhood AAD is not enough.It is currently the only listed non-pathogenic fungi microecological preparation.It bear hydrochloric acid in gastric juice,bile and a variety of digestive enzymes,naturally resistant to all antibiotics.It can accelerate the intestinal normal flora balance, antimicrobial activity,antitoxin unique mechanism of action of function,nutrition effect,etc. A recent meta-analysis of the literature shows that clinician can control of children suffering from diarrhea by it. SB can shorten duration of diarrhoea and hospitalization.The author selected in our department to antibiotic treatment in children with pneumonia and98cases as the observation group, from2007to2009with pneumonia records of92cases as control group, retrospective analysis of the clinical data. To investigate the SB in infantile antibiotic-associated diarrhea in prevention, and improve the understanding of the clinical pediatrician.Materials and Methods1The selection of object of studyThe observation group from October2011to January2013in our hospital98cases of children with pneumonia aged1month to3years old,male46cases, female42cases. Antibiotic treatment for7days or more.Antibiotics were cephalosporins, intravenous administration.To eliminate:when selected,there is diarrhoea or occurrence diarrhoea within48h after admission; Receive Long-term immunosuppressive therapy of children;With congenital malformations;In a critical condition;Rounding out the top2weeks received probiotics treatment of children. Diagnosis bronchiolitis. Diagnosis of rotavirus enteritis. Accept the Chinese patent medicines have side effects in the treatment of diarrhea. Control group92cases (2007-2009), In the process of treatment in children with pneumonia do not use any probiotics.The treatment group and control group on gender,age and disease index,there was no statistically significant difference, comparable.2The object of study of packet processingThe observation group was collected from October2011to January2013in our hospital98cases of children with pneumonia aged1month to3years old,male48cases, female50cases, age from January to3, January to1years in71cases,1～3years old in27cases, were full-term birth, all without exception. Antibiotic treatment for7days or more.Antibiotics were cephalosporins, intravenous administration.To eliminate:when selected,there is diarrhoea or occurrence diarrhoea within48h after admission; Receive Long-term immunosuppressive therapy of children;With congenital malformations;In a critical condition;Rounding out the top2weeks received probiotics treatment of children. Control group92cases (2007-2009), In the process of treatment in children with pneumonia do not use any probiotics.The observation group and the control group in gender,age, use of antibiotics and the severity of the days, no significant difference, comparable.3Statistical analysisData using SPSS17.0statistical software analysis,the rate of two groups of comparisons using x2test,Duration of diarrhea compared by t test. P<0.05is the difference has statistics significance.ResultsObserved within7days of observation group of98cases of AAD22example, incidence of22.45%,6cases of severe diarrhea, incidence of6.12%,the duration of diarrhea (2.89±0.63) d; AAD28cases of control group,92cases appeared, incidence was30.43%,8cases of severe diarrhea, incidence of8.70%,the duration of diarrhea (4.38±0.71) d. The duration of diarrhea is similar between the two groups was statistically significant (t=5.39, P<0.01).ConclusionsSaccharomyces boulardii can effectively reduce the incidence of pneumonic pediatric antibiotic-associated diarrhea,shorten the duration of diarrhea and diarrhea course,conducive to children illness recovery.