Probiotcs For Prevention Of Antibiotic Associated Diarrhea-clinical Study

Objective: Infants and children is high risk groups to infectious diseases, the treatment to infectious diseases mainly use antibiotics, irrational use of clinical antibiotics and broad-spectrum antibiotic make the incidence of antibiotics associated diarrhea on the rise. This research counted diarrhea occurrence of children patient with antibiotics, we understand the incidence of antibiotic associated diarrhea of different age groups, the incidence of diarrhea caused by various antibiotics and prevention and treatment effect of applying different probiotics, it can provide basis for reasonable choice of antibiotics and prevention and treatment of diarrhea.Method:We selected respiratory tract infective 3 years old the following children with antibiotics of pediatric ward in our hospital, they were randomly divided into three groups, with exception of the pre-hospital diarrhea, with the exception of improper feeding, catching a chill in belly. One group was given antibiotics such as conventional treament, at the same time the other tow groups were give different oral probiotics. Children with or without diarrhea within 7 days in hospital was observed. All children in group were divided into under one age old and more than one year old, diarrhea incidence was counted.Statistical treatment: All data is analyzed by the software of Spss 17.0. Each group of measurement data and two independent sample mean comparison were usd t test, according with normal distribution and homoscedasticity of the data. The data of non-normal distribution and heteroscedasticity were used nonparametric rank-sum test; attribute data comparison between groups was used by ?2 test. P<0.05 is statistical significance.Results:1 Age and sex of three groups children was no statistical difference(P>0.05). The incidence of diarrhea of three groups children was statistical difference(P<0.05), The children diarrhea incidence of probiotics was much smaller than the control group;2 Diarrhea incidence of different probiotics group were statistical differeence(P<0.05), children diarrhea incidence of saccharomyces boulardii was lower than that of bifidobacterium lactobacillus sanlian living bacterium, it was statistical differeence(P<0.05);3 The diarrhea incidence of difference age groups were statistical differeence(P<0.05). the incidence under one year old was biger than over one year old;4 The children diarrhea incidence of difference antibiotics were no statistical difference(P>0.05). The children diarrhea incidence of combined using antibiotics groups and that of using single antibiotics groups were no statistical difference(P>0.05).Concusion:1 Application of antibiotics with oral probiotics have a preventive effect on antibiotic associated diarrhea.2 For prevention of antibiotic associated diarrhea, oral saccharomyces boulardii was better than oral bifidobacterium lactobacillus sanlian living bacterium.3 Diarrhea incidence of antibiotics in children under one year old is higher than that of more than one year old.4 Diarrhea incidence of difference antibiotics group with diarrhea was no statistical difference to that of single antibiotics group.5 Combined use of antibiotics groups was no statistical difference to that of single antibiotics groups.