The Clinical Symptoms Of Guben Wenfei Huoxue Recipe Treatment The Sixty Aged COPD Combined PH

ObjectiveWe have observed COPD and PH sufferers’ change of Grade change ofclinical symptoms, six-minute-walking test, pulmonary arterypressure and B-type natriuretic peptide，Nt-pro-BNP, and discussedthe effect Guben Wenfei Huoxue Recipe having on the concentration ofNt-pro-BNP. Thus, we can lower the pulmonary artery pressure, improvethe function of cardio-pulmonary and clinical symptoms, In order toprovide an effective treatment method for delay or prevent thedevelopment of pulmonary heart disease.MethodsWe divide the sixty aged COPD combined PH sufferers into remedy groupand comparing group equally and randomly. Generally, we give theremedy group expectant treatment,such as, anti-infection,reducingphlegm,relieving asthma, releasing bronchospasm, oxygen therapy,lessening pulmonary artery pressure and allopathic remedy. As for theremedy group,we use Guben Wenfei Huoxue Recipe on the basis of normalwestern medicine treatment, one dose a day, two times each day, two course of continuous treatment(fifteen days means a course). Then wesurvey, grade and analyse relatively the change of this two groupsfifteen and thirty days clinical symptoms, pulmonary artery pressure,six-minute-walking test and Nt-pro-BNP.Results1.Grade change of clinical symptoms: After thirty-day treatment,remedy group sufferers show lower clinical symptoms grade. Comparingwith the comparing group,it has statistics difference(p<0.05).Putting this two groups together, it has statistics meaning(p<0.05).2.Change of pulmonary artery pressure: After thirty days, the remedygroup’s pulmonary artery pressure dropped. Comparing with theperformance before the treatment, it has statistics difference(p<0.05). Putting this two groups together, it has statisticsmeaning(p<0.05).3.Six-minute-walking test: After thirty days,the two group suffererswalk longer. Comparing with the performance before the treatment, ithas obvious statistics difference (p<0.05). Putting this two groupstogether, it has statistics meaning(p<0.05).4.Peripheral Blood Nt-pro-BNP level: After two course of treatment,the two groups show drop on the plasma Nt-pro-BNP content. After thirtydays, comparing with the performance before the treatment, it hasobvious statistics difference (p<0.01); Putting this two groupstogether, it has statistics meaning(p<0.05).5.Follow-up after treatment, after three month, the treatment grouppatients were readmitted for6persons (10times), the control grouppatients were readmitted for12persons（18times）, the comparisonbetween two groups, the treatment group in improving the prognosisof patients, reduce readmission rate than control group(p<0.01). 6.Correlation analysis:According to the correlation analysis byPearson, Nt-pro-BNP, clinical symptoms (r=0.345,p<0.05) andpulmonary artery pressure(r=0.345,p<0.05) has positive correlation;While, Nt-pro-BNP and distance in six-minute-walking test hasnegative correlation(r=-0.345,p<0.05).ConclusionGuben Wenfei Huoxue Recipe can improve the aged COPD combined PHsufferers’ clinical symptoms, reduce pulmonary artery pressure, andpostpone the further deterioration of lung function. Furthermore ithas one of a possible mechanism effects on the decrease of plasmaNt-pro-BNP level.