The Correlation Study Of Chronic Obstructive Pulmonary Disease Complicated With Pulmonary Hypertension And CRP,IL-6 And BNP

Objective: Based on c-reactive protein(CRP)and interleukin-6(IL-6),and b-type brain natriuretic peptide(BNP)detection,to observe the relationship between inflammatory response and Chronic obstructive pulmonary disease(COPD)complicated with pulmonary hypertension.Methods:1 Subjects: From January 2015 to November,71 cases of chronic obstructive pulmonary disease(41 males and 30 females,mean age 71.2± 6.3 years)in the department of respiratory medicine of Third Affiliated Hospital of Hebei North University were selected.The subjects were in accordance with the diagnostic criteria of chronic obstructive pulmonary disease(COPD)established in 2013 by the Chinese Association of respiratory diseases branch of the Chinese Medical Association,Post bronchodilator,FEV1 / FVC<70% showed persistent airflow limitation.All the selected patients were in accordance with the COPD diagnosis standard established in 2013,which was formulated by the respiratory disease branch of the Chinese Medical Association: FEV1 / FVC<70%,after inhalation of bronchial diastolic agent,indicating the presence of persistent airflow limitation.2 Lung function testPulmonary function test was performed in all selected patients after admission,the main indicators: the first second forced expiratory volume(FEV1),forced vital capacity(FVC),FEV1 accounted for the estimated percentage(FEV1%)and FEV1 / FVC.3 Measurement of pulmonary artery systolic pressureColor Doppler echocardiography detection: in a quiet state,all the selected COPD patients were detected in the pulmonary artery systolic blood pressure(PASP)by professional doctors by color Doppler echocardiography in functional section of our hospital.To 36 mm Hg as the boundary values,The patients were divided into two groups: 1.PASP ?36 mm Hg,COPD complicated with pulmonary hypertension group(COPD-PH group);PASP < 36 mm Hg,COPD pulmonary pressure normal group(COPD group).4 Determination of CRP,IL-6 and BNPCRP,IL-6 detection:On the second day of admission,all subjects were taken fasting venous blood 4m L,3500 r /min centrifugation,remove serum after 5 minutes of centrifugation,Placed-70 degrees Celsius to save for the test.Serum C reactive protein(CRP)was determined by immune assay(PETIA),serum interleukin-6(IL-6)was determinated by enzyme linked immunosorbent assay(ELISA).BNP detection: take the fasting venous blood 4ml,3500 r /min centrifugation.Remove plasma after 5 minutes of centrifugation,chemiluminescence microparticle Immuno Assay(CMIA)for the detection of BNP.Result:1 There was no significant difference in gender,age,smoking index and body mass index between the two groups of COPD complicated with pulmonary hypertension group and COPD group(P>0.05).2 Comparison of pulmonary function index of COPD complicated with pulmonary hypertension group and pulmonary pressure normal group,the difference between the two groups had no statistical significance(P>0.05),pulmonary function index including :Forced expiratory volume in one second(FEVl),forced vital capacity(FVC),FEVl percentage of predicted value(FEVl%)and FEVl / FVC.3 Comparison of pulmonary artery systolic pressure(PASP)in COPD complicated with pulmonary hypertension group and COPD group by color Doppler echocardiography show:PASP in pulmonary hypertension group was significantly increased,and the difference was statistically significant(P< 0.05).4 CRP,IL-6 and BNP in COPD complicated with pulmonary hypertension group was higher than those with normal pulmonary pressure,and the difference was statistically significant(P<0.05).5 Correlation analysis: PASP and CRP,IL-6,BNP paribas has positive correlation,r values were respectively 0.521,0.507,0.602,P<0.05.Conclusion: The serum inflammatory factor CRP and IL-6 in COPD complicated with pulmonary hypertension group was higher than COPD group,and plasma BNP levels in pulmonary hypertension group was higher than COPD group,the difference was significant(P<0.05).Correlation analysis: there was a positive correlation between PASP and IL-6,CRP,BNP.These suggest that inflammation response may be related to COPD complicated with pulmonary hypertension,and BNP can be used as early monitoring index of COPD complicated with pulmonary hypertension.