| Objective: To observe the effects on the ovarian and uterine hemody-namics for the patients with emmeniopathy syndromes of excess cold byWenjingtang.Methods: Thirty patients were selected with the standards of cold accum-ulation caused blood stasis including ten dysmenorrhea, six delayed menstr-uation, six hypomenorrhea and eight amenorrhea as well as the patients withthe oldest age of thirty-five, the least age of twenty-one and the average age oftwenty point forty five. Twenty married and ten unmarried people wereinvolved in. The longest course of disease was six years while the shortest wasone year, and the average of disease was three point fourteen years. Thehighest ranking score of symptom was eighteen, the lowest was six, and theaverage was eleven piont thirteen.Drew10ml blood from the cubital vein of patients sitting on the seatwith dysmenorrheal, hypomenorrhea and delayed menstruation at the anymenstrual cycles of11,12and13in the morning. The patients withamenorrhea should be prepared for blood collection at any time. The serum isseparated by anti-freezing and centrifugation, and then put it in the-20℃refrigerator for further measurement. The content of same group of FSH(Follicle Stimulating Hormone), LH (Luteinizing Hormone), E2(Estradiol), P(Progesterone),T(testosterone) in patients’ serum was assayed by RadioImm u-noassay analysis technique．GE LOGIQ-3color Doppler，Frequency of5~10MHz were used to monitor the ovarian, uterine artery blood flow, and level ofOVVOL, AFC and SFD at the same day.The patients with emmeniopathy of excess cold were treated withWenjingtang for one course of treatment (ChenZiMing the collection ofwoman prescription). Three-month menstrual cycle was as one course of treatment. During the observed course, the patients did not have any otherherbs or western drugs. On the fourth menstrual cycle, the patients werecollected blood. The methods of collecting blood, collecting time andpreserving were the same as previous.Thirty healthy women were taken as matched group (normal group forshort) besides the patients with cardiovascular and cerebrovascular diseases,liver and kidney disease, suprarenal gland, thyroid, hypophysis and otherendocrine disease, neuropsychosis, hematologic disease, etc. Comparing withthe patient group, there was no significant difference with each other. Themethod, time and test index of blood collection were same as above. Observethe improvement of clinical symptoms and traditional Chinese medicinesyndromes at pre-treatment and post-treatment phase as well as the changes ofovarian and uterine hemodynamics for the patients with menopathy of excesscold and its effects on reproductive endocrine.Result:1Comparison of patient group and control group:1.1The content of serum genital hormones: The level of serum FSH, LH, E2and T in patient group dropped remarkably than control group (P＜0.01).There was no statistical significant in serum P (P＞0.05).1.2Ovarian arterial: The level of PSV of ovarian arterial in patient group wassignificantly lower than control group(P＜0.01), The level of RI in patientgroup were higher significantly than that of control group(P＜0.01); The levelof PI in patient group were higher than that of control group(P＜0.05).OVVOL, AFC and SFD of patient groups were lower than that of controlgroup, but the results were not statistical significant (P＞0.05).1.3Uterine arterial: The level of PSV of uterine arterial in patient group wasobviously lower than that of control group (P＜0.01), The level of RI and PIwere significantly higher than that of control group (P＜0.01). The resultswere statistical significant, though the endometrium thickness was lower thanthat of control group, the results were not statistical significant.2Comparison of pre-treatment and post-treatment in three groups: 2.1The content of serum genital hormones: After treated, the post-treatmentgroup’s level of serum FSH, LH, E2and T were increased obviously than thatof pre-treatment (P＜0.01), but there was no statistical significant in serum P(P＞0.05).2.2Uterine arterial: The post-treatment group’s level of PSV of uterine arterialwas higher obviously than that of pre-treatment, the results were statisticalsignificant (P＜0.01); The level of PI and RI of uterine arterial inpost-treatment group was lower obviously than that of pre-treatment, theresults were statistical significant (P＜0.01); The endometrium thickness ofpost-treatment was higher than that of pre-treatment, but the results were notstatistical significant.2.3Ovarian arterial: The post-treatment group’s level of PSV of the ovarianarterial was significantly increased than that of pre-treatment, the results werestatistically significant (P＜0.01); The level of RI of the ovarian arterial wasobviously lowered than that of pre-treatment (P＜0.01), the results werestatistically significant; The level of PI of the ovarian arterial was loweredthan that of pretreatment (P＜0.01), the results were statistically significant (P＜0.05); After treated, the levels of OVVOL, AFC and SFD of patient groupwere higher than that of pre-treatment, but the results were not statisticalsignificant (P＞0.05).3The relationship between the ovarian and uterine hemodynamics and serumgenital hormones: The levels of ovarian arterial PSV and E2were positivelinear correlation (P＜0.01), the correlation coefficient was-0.613; The levelsof ovarian arterial PSV and FSH were negative linear correlation (P＜0.01),the correlation coefficient was-0.639, the results were statistically significant(P＜0.01); No relationship between the levels of ovarian arterial PI, RI and E2(P＞0.01); The level of uterine arterial RI and E2were negative linearcorrelation (P＜0.01), the correlation coefficient was-0.485, the results werestatistically significant; No relationship between the levels of uterine arterialPSV, PI and E2(P＞0.01), the results were not statistically significant. Conclusion:1The level of serum genital hormones for the patients with emmeniopathysyndromes of excess cold dropped down.2The ovarian and uterine hemodynamics for the patients with emmeniopathyof excess cold shows the status of hypoperfusion and high resistance.3Wenjingtang can improve the level of genital hormone for patients withemmeniopathy of excess cold effectively, reduce vascular resistance, improvethe status of cold stagnation and blood stasis, representing the effectivity ofwarm channel and expelling cold by increasing the blood perfusion for ovarianand uterine arterial. |
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