Analysis Of The Related Influential Factors Of Perinatal Birth Defects

A birth defect is defined as any abnormality affecting body structure or function that is present from birth.The birth prevalence of all genetic birth defects combined ranges from a high of82to a low of39.7per1,000live births worldwide. Many of the highest birth prevalence rates are found among the world’s poorest countries, while many of the lowest rates are found among the world’s wealthier countries, with the exception of countries where common recessive disorders and marriages between first cousins and other close relatives are common. Serious birth defects can be lethal. For those who survive, these disorders can cause lifelong mental, physical, auditory or visual disability.At least3.3million children under five years of age die from birth defects each year.To date,more than7,000different birth defects of genetic or partially genetic origin have been identified.Birth defects are a global problem, but their impact is particularly severe in middle-and low-income countries. The proportion of births with birth defects as well as the absolute number of births are much higher in middleand low-income countries than in high-income countries because of sharp differences in maternal health and other significant risk factors, including poverty, a high percentage of older mothers, a greater frequency of consanguineous marriages and the survival advantage against malaria for carriers of sickle cell, thalassemia, and glucose-6-phosphate dehydrogenase (G6PD) deficiency genes. Comparable data could not be derived for birth defects due to post-conception damage caused by maternal exposure to teratogens, such as alcohol,drugs, some infections and a number of toxic environmental agents.As with birth defects of genetic or partially genetic origin, post-conception birth defects are more common in low-and middle-income countries,where the potential for exposure to teratogenic agents is greater and fewer preventive measures are in place than in high-income regions.We must take highlight care and prevention of birth defects as an essential and integral part of women’s, maternal, newborn, and child health programs in all countries. Fortification of the grain food supply with folic acid has produced a sharp decline in neural tube defects each year.Collection of information on related influential factors such as precedent pregnant examination,taking folic acid,pregnant examination, and so on,to provide evidence for the control of birth defects.ObjectiveTo Investigate the relationship between birth defects and the related factors, find out some effective measuresrelated factors which reduce birth defects.Subjects and Methods1SubjectsWe studied254birth defects served in the study group.They were born in related birth defects monitoring hospital in henan province from October1,2011to March31,2012.762normal newborn infants were observed as control and matched for birthing at the same day and the same hospital. We used case-control for the study.2MethodsWe fill in the birth defects card and self-designed questionnaire by henan province in potential prenatal and perinatal which includes26items. Training the relevant person in charge of the investigation of hospital to ensure that useing unified language in the process. We checked the data by10percent.3Statistical Methods We encode correlated variable and input Excel spreadsheet. Chi-square was used to compare the basic situation. By means of univariate analysis to discuss the date of each factors,and then statistically significant variables included in the multivariate model fitting.All information use17.0for statistical analysis. a=0.05Results1.The difference of Case group and control group have no statistics significance on age、 nation and the sex newborns (P>0.05). The balanced principle is considered.2.Univariate analysis show that check-ups,precedent pregnant examination, taking folic acid,pregnant examination are protection factors for birth defects,history of the cold of early pregnancy,abnormal pregnancy history,pregnancy complications and multiple pregnancies are risk factors for birth defects.3.Multivariate analysis showed that the check-ups and pregnant examination are protection factors,abnormal pregnancy history,touch with harmful material during periconceptional,pregnancy complications are risk factors for birth defects.ConclusionThe check-ups,precedent pregnant examinationand and pregnant examination are protection factors,effective measures to reduce or avoid birth defects;abnormal pregnancy history,touch with harmful material during periceonceptional are risk factors for birth defects,the key points of the prevention of birth defects is interfere it as early as possible;pregnancy complications are risk factors for birth defects, the effective methods to reduce birth defects are must be realized, timely diagnosis intervened in time.