Perinatal Surveillance Of Birth Defects In Zhengzhou City

Birth defects (BD) or congenital anomalies (CA) refers to the genetic, environm--ental or genetic and environmental factors, the embryo developmental anomalies in--duced by individual organ structure, metabolism and behavioral and psychological aspects of congenital anomalies.The193countries in the world each year the number of birth defects accounted for more than7,900,000, population6%, about3,300,000children under the age of5die each year of birth defects,3,200,000children lifelong disability. The total incidence of birth defects in China by87.7/10,000(1996) up to149.9/10,000(2010), the growth rate of70.9%, and there is still annual increasing in the proportion of2%.Not only the cause of death in children with birth defects, but also seriously affect the long-term quality of life, is a global public health problem.ObjectiveThe birth defects monitoring data of Zhengzhou city in2013were analyzed, including the overall occurrence status of the birth defects, prenatal diagnosis and characteristics, in order to improve the service quality of birth defects, the formulation of prenatal and postnatal care service policy and intervention measures to provide scientific basis for prevention of birth defects.Subjects and Methods1SubjectsBirth defects were monitored in the childbirths of normal deliveries and those of therapeutic induction of labor in120of the medical and health institutions at all levels with the conditions of delivery of Zhengzhou City, including six administrative districts and six county-level city, from October1,2012to March31,2013?2MethodsAdopting the monitoring project of focusing on publicity monitor and the national “The defect babies register card” and “Quarter Report Sheet on Babies” collect date.The hospital professional training of doctors confirmed to fill in the "report card" birth defects, quarterly report, then checked again.3Statistical MethodsAfter cheek and verification,the data was input into the computer to establish a database with Excel2007and then made statistical analysis with SPSS17.0.Comparison of the rate applies to2test.?=0.05.Result1The incidence of BD of Zhengzhou City was (126.3/10000), The perinatal mortality was6.99‰,of which67.75%were the deaths with BD.The first five BD of Zhengzhou city were congenital heart disease, multi-finger (toe), total cleft lip, deformity of external ear, congenital hydrocephalus. 2The prenatal diagnosis rate of BD was45.40%?The prenatal diagnosis with ultrasonography rate of the prenatal diagnosis was96.62%.The top three BD prenatally diagnosed were congenital heart disease,total cleft lip and congenital hydrocephalus,while the top three BD postnatally diagnosed were multi-finger (toe),deformity of external ear and total cleft lip.The first five BD of prenatally diagnosed rate were anencepha--lia,conjoined twins,cystic hygroma,other brain malformations and congenital hydrocephalus. The last five BD of prenatally diagnosed rate were deformity of external ear, and finger (toe), multi-finger (toe), small ears and external genital malformation.3The incidence of BD has seasonal difference, the highest incidence rate in winter(139.70/10,000), the lowest in spring (99.43/10,000); The highest incidence rate of total cleft lip was in summer (17.91/10,000), the lowest in spring (8.33/10,000);The incidence of BD in35years of age or older pregnant women the highest (162.20/10,000);male (142.35/10,000) incidence rate of birth defects is significantly higher than female (103.50/10,000), the incidence rate of the congenital heart disease, multi-finger (toe), external genital malformation,outer ear deformity, syndactyly,obstruction of urinary system malformations were higher than the female.The influential factors of group of birth defects of esophageal atresia or stenosis, chromosomal abnormalities and hermaphroditism higher than the proportion of non factor group, multiple group multiple malformations than single factor group.ConclusionBirth defects are the main causes of death of perinatal death.We should take prevention of BD. The first five BD of Zhengzhou city were congenital heart disease, multi-finger (toe), total cleft lip, deformity of external ear, congenital hydrocephalus We should strengthen the concern and research of above these Birth defects.The prenatal diagnosis rate is low, the standardized prenatal ultrasonography is needed, integrating more productive screening and prenatal diagnosis methods.The last five BD of prenatally diagnosed rate were deformity of external ear, and finger (toe), multi-finger (toe), small ears and external genital malformation.Strengthening the study of prenatal diagnosis method of these defects,then popularizing. More than35years in age group of birth defects is high-risk.We should do the best to give publicity to the prevention knowledge of BD.