Effects Of Curcumin In Different Time And Different Dosages On The Gastrointestinal Peristalsis Changes Caused By Atropine In Mice

Background:Functional dyspepsia is a common clinical syndrome in pediatric digestive system. The children usually repeatedly see a doctor, take several medicines, while the effect is not satisfied and some side effects are often obvious. Functional dyspepsia has serious influence on children growth and life. Looking for safe and effective therapy measures for functional dyspepsia is very necessary. Chinese herbal medicine that has smaller side effects is an important research direction on improving gastrointestinal peristalsis. Previous research in our laboratory found for the fist time that curcumin can significantly improve the gastrointestinal peristalsis abated by atropine. Curcumin effectively promoted gastrointestinal peristalsis and reduced the residue rate of stomach. The best time and dose of curcumin needs to be further clear.Objective:By giving different time and dose of curcumin in advance, to observe and compare the effects of curcumin on gastrointestinal peristalsis abated by atropine, and to find out the optimal time and dose of curcumin used by lavage, and to provide important theoretical basis for further experimental study and clinical applications.Methods:Male KM mice were randomly divided into different time and dose groups,8mice in each group. In different time groups, curcumin (200mg. kg-1. d-1) was administrated by lavage for lday,5day,1Oday and15day in different groups. In different concentration group, the mice were divided into100mg. kg-1. d-1,200mg. kg-1, d-1,300mg. kg-1. d’and400mg. kg-1. d-1groups. Curcumin was administrated by gastric lavage daily for l0days. After24hours for the last lavage of curcumin, the model of abated gastrointestinal peristalsis induced by atropine was used. The gastric residual rate and the motional rate of small intestine were detected using the ink lavage method.Results:In atropine group, the gastric residual rate was increased and the motional rate of small intestine was decreased obviously. The gastric residual rate and the motional rate of small intestine were no significant changes in curcumin lday and5day groups. While in curcumin l0day and15day groups, the gastric residual rate was decreased and the motional rate of small intestine was increased significantly compared with that in atropine group. There was no obvious difference in l0day and15day groups. In different concentration groups, curcumin(100mg.kg-1-400mg.kg-1) decreased the gastric residual rate and increased the motional rate of small intestine significantly. There was no difference in different concentration groups.Conclusion:1. Curcumin can significantly improve the gastrointestinal peristalsis decreased by atropine in mice. It has obvious effects on reducing functional injury of gastrointestine.2. Only more than100mg-kg-1.d-1of Curcumin giving by lavage for more than10days can significantly improve the gastrointestinal peristalsis decreased by atropine in mice.