Distribution And Evolution Of TCM Syndromes On Chronic Severe Hepatitis B

Object:To explore the distribution and characteristics of TCM syndromes、each stage syndrome factor-. the complications syndrome features of chronic severe hepatitis B(CSHB), discussed the rules of syndrome factor distribution and syndrome development on CSHBMethods:Take the forward-looking research method,99cases of patients with CSHB of our hospital in October2009to October2010were studied, Collect the clinical data at the time of diagnosis and various complications happens, including gender, age, biochemical index, blood coagulation function, A study of four diagnostic material including signs and symptoms, tongue and pulse presentations and TCM symptom complex total of80item was conducted and recorded. according to the syndrome factor theory, base on four diagnostic material, we use weight summation method respectively summarize overall syndrome factor、each stage syndrome factor^syndrome factors of each complications, to discusses the CSHB TCM syndrome factor distribution and syndrome development rules. All dates were test with SPSS17.0statistical software， Frequency were statistically description, using the X2to count data inspection comparison between groups. P<0.05is considered to have a statistical difference.Results:The statistical analysis of the results show that:(1) In the general symptoms(including signs and symptoms, tongue and pulse presentations) from high frequency to low show that:yellowish eye100%;yellowish body99%;yellowish urine99%; fatigue96%;wiry pulse95%; anorexia92%; waist pain92%; yellow fume smoke88%;face dull79%;vector gas83%; dislike of greasy food79%; tongue qualitative ecchymosis77%;palate tasteless74%;abdominal distension72%;mouth bitter70%; mouth sticky greasy64%; white tongue fur63%; will not under58%;tongue fur embellish56%; nausea55%;urination54%;body trapped heavy51%; abscesses50%;sluggishness50%.(2)In the overall syndrome factors distribution: Disease’s position syndrome factors:liver, spleen,kidney,gallbladder, stomach and intestine, heart,7kinds in all;Disease’s properties syndrome factors:wet, heat, Qi deficiency, qi stagnation, blood stasis, Yin deficiency, Yang deficiency, cold, phlegm, Qi upward, blood deficiency,11kinds in total. Higher frequencies of occurrence (>50%) disease’s position and properties syndrome factors are liver, spleen, kidney, gallbladder, wet, heat,Qi deficiency, qi stagnation, blood stasis.(3)In each stage,the syndrome factor’s distribution show that:liver, spleen syndrome factor in each stage are larger in common, the rate are close to100%, stomach and kidney syndrome factor incidence rate of each period is different, the difference was statistically significant (p<0.05), the stomach syndrome factor mainly in the middle and end stage, and,heart and kidney syndrome factor in the certificate of the frequency are constantly increasing; Wet, heat, Qi deficiency syndrome factor in the frequency of the occurrence in each stage are in a high degree, the difference have no statistically significant (a X2test:p>0.05)between each stage. Yin deficiency,Yang deficiency blood deficiency syndrome factor have statistical differences(p<0.05), in early stage acted more obvious; And blood stasis, sputum syndrome factor in the end stage performance more obvious, blood stasis syndrome factor distribution in each stage are different and have statistically significant (P<0.05).(4) Complications syndrome factors distribution shows:liver, spleen, Qi deficiency,qi stagnancy are have a high occurrence rate in each complications (frequency are close to100%). Ascites patients:kidney, stomach, blood deficiency, blood stasis syndrome factor have a higher frequency than those have no ascites patients, the difference have statistical significant (P<0.05). Patients with hepatic encephalopathy(HE):heart, sputum syndrome factors frequency are higher than those have no HE, the difference was statistically significant (P<0.05). Gastrointestinal bleeding patients:intestine, heart, Qi upward, blood deficiency syndrome factor have a high frequency than those have no Gastrointestinal bleeding, the difference was statistically significant (P<0.05). Infected patients:intestine, Yin deficiency, have a higher frequency than those negative, the difference was statistically significant (P<0.05). HRS patients:kidney, intestine, cold, Yang deficiency syndrome factors have higher frequency than those have no HRS, the difference was statistically significant (P<0.05).Conclusion:(1)General symptoms features:. Deficiency mixed with excess,Ben deficiency together with Biao excess.(2) Overall pathogenesis features:disease’s syndrome factors:liver, spleen, gallbladder kidney;Disease’s properties syndrome factor hot, damp,qi deficiency,blood stasis, qi stagnation, phlegm.(3) Syndrome features of each stage:wet, heat, Qi deficiency throughout the development of the diseases,on disease’s position:liver,spleen firstly, then the gastrointestinal,and then to heart and kidney;The properties of the disease:early are Yin deficiency, Yang deficiency, blood deficiency; With phlegm and blood stasis in the middle and end stage.(4) The syndrome features Of each complications:Ascites:Liver、spleen、 kidney disordered together, Qi,Blood stasis, water stagnation and joined in abdominal; HE:damp and hot humid evil poison closed inside, and the phlegmy heat disturbing the mind and heart, Gastrointestinal bleeding:Hot and humid implication, deficiency of spleen qi induce gastrointestinal bleeding; Infection:Damp, hot and humid evil poison embodiment, qi and Yin deficiency prompt of infection; HRS:Damp and hot accumulate at Zhongjiao, deficiency of Qi and Yang on spleen and kidney is the main symptoms of kidney syndrome features.