Correlative Study On Common TCM Syndromes And Inflammatory Factors In Newly Diagnosed Metabolic Syndrome

Objective: To analyze the relationship of compositions between PixushizuSyndrome and Qi-Yin Deficiency in the subjects with newly diagnosed MetabolicSyndrome; to investigate the correlation on this two TCM Syndromes and theinflammatory factors, TNF-αand hs-CRP; in order to provide objectiveparameters for prevention, development of the disease, inspection of clinicaleffect on MS, as well as the establishment of TCM Syndrome standards.Methods: Summary and evaluate the late advancement of MS in TCM and WestMedicine, by way of reviewing a great number of literatures in Western Medicineand Chinese Medicine. 60 subjects with newly diagnosed MS were divided intotwo groups: 30 with Pixushizu Syndrome and 30 with Qi-Yin Deficiency. 30healthy subjects with normal waist circumference (WC), normal tolerance,normal serum lipids, normal blood pressure were selected as control group.Fasting peripheral blood specimens were collected and centrifuged to obtainserum. Serum concentrations of Hs-CRP and TNF-αwere detected bychemiluminescence assay. Finally the parameters of the three groups wereanalyzed and evaluated.Results:1. Subjects of newly diagnosed MS in this study mostly containedcompositions of central obesity, high triglyceride(TG) level, high fastingplasma glucose (FPG) level.2. Pixushizu Syndrome and Qi-Yin Deficiency were the most common syndromesin subjects with newly diagnosed MS. Parameters among the three groups werecompared as follows:①Age, gender construction: no significant deviation(P＞0.05);②WC, TG, FPG: Pixushizu group＞Qi-Yin Deficiency group＞Controlgroup(respectively, P＜0.05 for all);③High density lipoprotein-cholesterol(HDL-C): Control group＞ Pixushizu group＞Qi-Yin Deficiency group(respectively, P＜0.05 for all);④Systolic blood pressure(SBP), Diastolic blood pressure(DBP): Qi-YinDeficiency group＞Pixushizu group＞Control group (respectively, P＜0.05for all);⑤Chanciness of combining hypertension: Qi-Yin Deficiency group＞Pixushizu group(P＜0.05);⑥Score of MS compositions: Qi-Yin Deficiency group＞Pixushizu group(P＜0.05).3. In subjects of newly diagnosed MS, the levels of TNF-αand hs-CRP werepositively correlated with the levels of WC, TG and FPG, but not significantlycorrelated with the levels of HDL-C, SBP or DBP.4. In subjects of newly diagnosed MS, the correlations between TCMSyndromes and the inflammatory factors, TNF-αand hs-CRP, were as follows:①TNF-α: Pixushizu group＞Qi-Yin Deficiency group＞Controlgroup(respectively, P＜0.05 for all);②hs-CRP: Pixushizu group＞Qi-Yin Deficiency group＞Controlgroup(respectively, P＜0.05 for all).5. Comparisons of the two common TCM Syndromes in newly diagnosed MS wereas follows:Compared to the Qi-Yin Deficiency group, Pixushizu group had itscharacteristics: greater WC, higher TG, higher FPG, higher TNF-αand hs-CRP;Subjects with Qi-Yin Deficiency had more chanciness of combing hypertension.Conclusions: In this study, we found that there was a state of chroniclow-grade inflammation in Qi-Yin Deficiency and Pixushizu Syndrome subjectswith newly diagnosed MS. The inflammatory extent was positively correlatedwith the levels of WC, TG and FPG. No significant correlations betweeninflammatory extent and the level of HDL-C, SBP or DBP were found. There werevarious inflammatory extents in different TCM Syndromes, which in Pixushizugroup was more serious than that in Qi-Yin Deficiency group.