Study On The Correlation Between Common TCM Syndromes And Metabolic Syndrome And Inflammatory Factors In Psoriasis Vulgaris

Objective:1.To investigate the incidence of metabolic syndrome in patients with common TCM syndromes of vulgaris psoriasis;2.To explore the incidence of metabolic syndrome and the related factors of induced psoriasis with metabolic syndrome of vulgaris psoriasis;3.To explore the differences between psoriasis vulgaris and non-psoriasis control group.4.To explore the inflammatory mechanism of psoriasis with metabolic syndrome and the common TCM syndromes of psoriasis with metabolic syndrome.Methods:1.Subjects The study was conducted in 445 cases of psoriasis patients from the Department of Dermatology,Guangdong Provincial Hospital of Traditional Chinese Medicine from October 2014 to December 2016.At the same time,a total of 450 healthy subjects were selected from the Department of Traditional Chinese Medicine and Physical Examination Center of Guangzhou Red Cross Hospital as the control group.2.Symptoms According to the Guangdong Provincial Hospital of Traditional Chinese medicine psoriasis TCM syndrome information collection table for psoriasis patients with symptom identification,and according to PASI score criteria for the score.3.Psoriasis and metabolic syndrome diagnostic criteria According to the "Chinese clinical dermatology" diagnosis of psoriasis diagnosis of psoriasis,if necessary,pathological biopsy for a clear diagnosis;according to 2009 IDF and AHA/NHLBI jointly developed The definition of a new metabolic syndrome(MS)for the diagnosis of MS.4.Inclusion criteria:(1)patients with psoriasis diagnosis;(2)non-psoriasis control group without inflammatory disease;(3)signed informed consent.5.Exclusion criteria(1)Essential hypertension;Primary diabetes mellitus(type ?);familial hyperlipidemia;(2)3 months of systemic use of over-dimensional A acid preparations,glucocorticosteroids and immunization Inhibitors;(3)those suffering from rheumatism,rheumatism,malignancy and immune system disorders.6.For the standard of patients with abdominal circumference,blood pressure detection,while the patient's gender,age,duration,smoking,drinking,exercise to inquire about the different syndromes of psoriasis patients and healthy control group lipid Metabolism(total cholesterol,triglyceride,high density lipoprotein cholesterol,low density lipoprotein cholesterol,fasting blood glucose,serum uric acid,creatinine,alanine aminotransferase,aspartate aminotransferase,fibrinogen,erythrocyte sedimentation,Of laboratory tests.7.Different levels of psoriasis patients with metabolic syndrome and healthy control group of patients with serum,by protein chip method to detect different inflammatory factors.8.Statistical analysis The statistical analysis software SPSS17.0 was used to analyze the data.The measurement data were expressed as the mean ? standard deviation(),the percentage of the count data was used,and the two groups were compared with the x2 test.Two groups of factors Comparison of two factors using multiple levels of factorial design and analysis of variance,single factor group comparison between single-factor analysis of one-way variance(one way-ANOVA),variance Qi when using SNK(Student-Newman-Keuls)The difference was statistically significant(P<0.05).There was no significant difference between the two groups.Results:1.445 cases of psoriasis patients with blood heat syndrome in 48 cases,170 cases of blood stasis,blood syndrome,227 cases,of which the majority of blood dry syndrome.2.45 cases of psoriasis in patients with recurrent metabolic syndrome in 172 cases,the incidence was 38.7%,450 cases of non-psoriasis control group occurred in 114 cases of metabolic syndrome,the incidence was 25.3%,after x2 test,X2 = 18.25,P<0.05,psoriasis with metabolic syndrome and non-psoriasis control group compared to the difference was statistically significant.3.The levels of abdominal circumference,systolic blood pressure,fasting blood glucose,triglyceride,low density lipoprotein,alanine aminotransferase,aspartateaminotransferase,potassium ion,calcium ion,prothrombin time,fibrinogen,thrombin Time,and high sensitivity C-reactive protein were higher than the control group,the two groups were statistically significant.4.In the common TCM syndromes of psoriasis vulgaris,18 cases of hematopoietic syndrome and 18 cases of metabolic syndrome were found.The incidence of hematopoietic syndrome was 38.2%in 80 cases.There was no significant difference in the incidence of metabolic syndrome between the three syndromes,but it was statistically significant compared with the control group.5.The three common TCM syndromes(blood heat syndrome,blood-dry syndrome,blood stasis syndrome)and non-psoriasis control group were common in abdominal circumference,systolic blood pressure,fasting blood glucose,triglyceride,low Density lipoprotein,alanine aminotransferase,aspartate aminotransferase,potassium ion,calcium ion,prothrombin time,fibrinogen,thrombin time,high sensitivity C-reactive protein compared with three common TCM syndromes were associated with non-psoriasis Disease control group were different,but there was no significant difference between the three syndromes.6.The severity of PASI was significantly different between the three common TCM syndromes in the patients with psoriasis vulgaris,and the PASI score(7.32 ±1.82)in the Xuehua group was significantly higher than that in the blood stasis group(5.55 ± 1.09)(5.31 ± 1.57),F = 13.353,P = 0.000<0.05.7.48 cases of psoriasis patients with psoriasis in 338 cases,of which 143 eases of metabolic syndrome,the prevalence rate of 42.3%;107 cases of female psoriasis patients,with metabolic syndrome in 29 cases,the prevalence rate of 27.1%;The prevalence of males was significantly higher than that of females(x2 = 7.924,P =0.005<0.05).8.445 cases of psoriasis patients with different age groups with the prevalence of metabolic syndrome,20-30 years of age between 27.7%,30-40 years old between 37.1%,40-50 years old between 40.0%;46-60%between 50-60 years old;50%for the age of 60 years;by chi-square test,x2 = 9.849,P = 0.043<0.05,the incidence of various age groups were statistically significant.9.445 cases of psoriasis patients with different metabolic syndrome in the incidence of different rates,between the different course of the statistically significant,the incidence of 5 years of metabolic syndrome score was 28.2%;5 to 10 years combined with metabolic synthesis And the rate of metabolic syndrome was 42.1%in 10-20 years.The incidence of metabolic syndrome in patients with psoriasis was 48.6%over 20 years.The chi-square test was x2 = 8.696,P = 0.034<0.05,so the different course of metabolic syndrome with the incidence of significant differences.10.445 cases of psoriasis patients with a history of smoking in 103 cases,of which 49 patients with metabolic syndrome,the incidence rate was 47.6%;no smoking history of psoriasis patients with 342 cases,which combined with metabolic syndrome Patients with 123 cases,the incidence rate of 36.0%,after four square chi-square test,x2 = 4.498,P = 0.034<0.05,so the history of smoking for psoriasis patients with metabolic syndrome incidence rate was statistically significant significance.11.445 cases of psoriasis patients with a history of drinking 94 cases,of which 43 patients with metabolic syndrome,the incidence rate of 45.7%;no history of drinking psoriasis in 351 cases,of which the metabolic syndrome was 129 cases,the incidence rate of 36.8%,by the four-dimensional chi-square test,x2 = 2.529,P = 0.112>0.05,so drinking or psoriasis patients with metabolic syndrome incidence was not statistically significant.12.Psoriasis patients with metabolic syndrome,psoriasis patients without metabolic syndrome,no psoriasis without metabolic syndrome,three groups of serum 40 kinds of inflammatory factors were found between the three groups of inflammatory factors were statistically significant IL-6(P = 0.026<0.05),IL-6R(F = 3.963,P =0.036<0.05),PDGF-BB(F = 4.738,P = 0.021<0.05),RANTES(F = 4.970,P = 0.018<0.05);three common TCM syndromes syndrome,blood deficiency syndrome,blood stasis syndrome psoriasis with metabolic syndrome in patients with serum 40 kinds of inflammatory factors The difference was statistically significant:IL-11(F = 5.583,P =0.021<0.05),IL-17(F = 11.084,P = 0.002<0.05);the other blood-heat syndrome,(P<0.05),and the difference was statistically significant(P<0.05),and the difference was statistically significant(P<0.05),and the difference was statistically significant IL-5(F=0.286,P = 0.026&It;0.05),IL-5(F = 0.05),IL-13(F = 2.989,P = 0.049<0.05),MCSF MIP-1b(F = 3.486,P = 0.024<0.05),PDGF-BB(F = 4.19,P = 0.024<0.05),MIP-1a(F = P = 0.015&It;0.05),RANTES(F = 4.092,P = 0.017&It;0.05).Conclusion:1.The incidence of psoriasis with metabolic syndrome is higher than normal healthy people;2.Psoriasis affects the patient's blood sugar,lipid metabolism,coagulation,ion,liver and kidney function,inflammatory markers,so that psoriasis may be affect metabolism of the body;3.There was no significant relationship between the common syndromes of TCM and the incidence of metabolic syndrome in patients with psoriasis vulgaris.4.TCM syndromes are closely related to the severity of psoriasis;5.TCM syndromes may have no effect on blood glucose,lipid metabolism,ion,coagulation function,liver and kidney function and inflammatory markers in psoriasis vulgaris;6.Sex,duration,age and psoriasis with metabolic syndrome is closely related;7.Smoking is a possible risk factor for psoriasis with metabolic syndrome;8.GM-CSF,IL-5,IL-8,IL-13,MCSF,MIP-la,MIP-lb,PDGF-BB and RANTE may play an important role in the pathogenesis of psoriasis with metabolic syndrome.IL-11,IL-17 may be type of biomarkers in different common TCM syndromes of psoriasis vulgaris,thereby inferring the two biomarkers that may play an important role in the severity of psoriasis vulgaris.